Evidence map›Paper›PMID 41724833›Full record

ArticleNeuroradiology2026

Peak width of skeletonized mean diffusivity as a quantitative imaging marker of white matter alterations in MRI-negative temporal lobe epilepsy: validation with demographic covariate adjustment.

Suxiang Jiang, Tingting Zhu, Jing Wang, Xianhong Lin, Xiaotong Wu, Jianjia Zhang, Zhongxing Luo, Yalei Shang, Xiaowei Xu

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Suxiang Jiang *Department of Radiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Tingting Zhu *Department of Radiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Jing WangDepartment of Radiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Xianhong LinDepartment of Radiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Xiaotong WuSchool of Biomedical Engineering, Shenzhen campus of Sun Yat-sen University, Shenzhen, China.
Jianjia ZhangSchool of Biomedical Engineering, Shenzhen campus of Sun Yat-sen University, Shenzhen, China.
Zhongxing LuoDepartment of Radiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Yalei ShangDepartment of Radiology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Xiaowei XuDepartment of Neurology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China. xuxw23@mail.sysu.edu.cn.

Funding

the China Association Against Epilepsy-Neuroracle EEG Fund (CB-2022-016).
6 · The paper itself

Abstract

purposeThis study evaluated the peak width of skeletonized mean diffusivity (PSMD) as a quantitative imaging marker in patients with magnetic resonance imaging-negative (MRI-negative) temporal lobe epilepsy (TLE), accounting for age and sex effects.

methodsThis retrospective study included 34 MRI-negative TLE patients and 40 age- and sex-matched healthy controls (HCs). PSMD was calculated using tract-based spatial statistics and histogram analysis. Hierarchical regression identified PSMD determinants. Receiver operating characteristic analysis compared uncorrected and age- and sex-corrected PSMD, with the latter validated by 10-fold cross-validation.

resultsPSMD was significantly elevated in patients versus HCs (2.545 × 10

conclusionPSMD is a quantitative marker of diffuse white matter pathology in MRI-negative TLE, modulated by demographic factors. Consistent sex effects across groups indicate biological rather than disease-specific variation. Demographic adjustment improves specificity but not overall accuracy, supporting PSMD for group-level cross-sectional studies. Sex effects must be controlled for in white-matter diffusion MRI.

Indexed as

Diffusion Tensor ImagingEpilepsy, Temporal LobeImage Interpretation, Computer-AssistedWhite MatterAdultFemaleHumansMaleMiddle AgedReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityDiffusion tensor imagingMagnetic resonance imaging-negativePeak width of skeletonized mean diffusivityTemporal lobe epilepsy

Identifiers

PMID41724833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.