ArticleScientific reports2026
Immunomediator expression in human periodontal ligament MSCs varies depending on surface CD146 expression.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Isolating mesenchymal stromal cell (MSC) subpopulations with improved quality based on specific surface markers, such as CD146, is one approach to enhance their therapeutic potential. However, there is limited information on the cytokine-boosted immunomodulatory mechanisms between CD146-expressing and non-expressing MSCs across various inflammatory conditions. This study seeks to address this gap. MSCs from the human periodontal ligament (hPDL-MSCs) were treated with interleukin-(IL)-1β, interferon-(IFN)-γ, or tumor necrosis factor-(TNF)-α, investigating the expression of IDO-1, PD-L1, PTGS-2, and TSG-6 between CD146
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