Evidence map›Paper›PMID 41724757›Full record

ReviewSignal transduction and targeted therapy2026

Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer.

Sihui Zhang, Lin Yuan, Ping Lin, Gen Yang, Xikun Zhou, Jinfu Xu, Min Wu, Yongye Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sihui Zhang *College of Life and Health Sciences, Northeastern University, Shenyang, China.
Lin Yuan *Laboratory of Research in Parkinson's Disease and Related Disorders, Health Sciences Institute, China Medical University, Shenyang, China.
Ping LinBiological Science Research Center, Southwest University, Chongqing, China.ORCID http://orcid.org/0000-0002-4281-2440
Gen YangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Xikun ZhouDepartment of Biotherapy, Cancer Center & State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Tianfu Jincheng Laboratory Chengdu, Jincheng, China.ORCID http://orcid.org/0000-0001-6768-2382
Jinfu XuDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Min WuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China. minwoo2022@126.com.ORCID http://orcid.org/0000-0003-1205-982X
Yongye HuangCollege of Life and Health Sciences, Northeastern University, Shenyang, China. huangyongye88@163.com.ORCID http://orcid.org/0000-0002-9083-250X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82201594
6 · The paper itself

Abstract

From a neuroscience perspective, cancer neuroscience has emerged as a subfield of cancer research. Presumable mechanisms underlying cancer-related neuronal activity (termed neurosciences) include the induction and modulation of signaling pathways that govern cell fate determination and emotional responses (anxiety and stress), such as structural molecules (synaptic structures and current transduction) and secretory substances (neurotransmitters, cytokines, hormones and neuropeptides). In the past 3 years, these neuronal activities, which can either promote cancer growth or be hijacked by cancer cells to support tumor survival and invasion, have been widely demonstrated to be closely related to cancer progression. The molecular mechanisms are also being refined. Despite their great promise, translating neuroscientific discoveries into clinically actionable strategies for cancer diagnosis, prognosis, and treatment remains a formidable task. In this comprehensive review, we attempt to provide a full account of the intersection between neuroscience and cancer research. From the perspective of cancer neuroscience, we fully discuss the potential signaling molecules and their regulatory mechanisms, as well as targets and emerging therapeutic strategies that control tumor progression via multiomics approaches. Overall, cancer neuroscience may have unprecedented potential for understanding neuronal functions and cancer development, ultimately offering the significantly improved cancer treatment.

Indexed as

NeoplasmsSignal TransductionAnimalsHumans

Identifiers

PMID41724757
PMCPMC12926231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.