Evidence map›Paper›PMID 41724713›Full record

ArticleThe New phytologist2026

Metacaspases contribute to the cellular response to heat stress in a marine diatom.

Mai Sadeh, Daniella Schatz, Shifra Ben-Dor, Avia Mizrachi, Shiri Graff van Creveld, Amichai Zafrin, Assaf Vardi

Abstract read
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mai SadehDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.ORCID https://orcid.org/0009-0003-8492-017X
Daniella SchatzDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0003-2740-8391
Shifra Ben-DorLife Science Core Facilities, Weizmann Institute of Science, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0001-9604-1939
Avia MizrachiDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0001-7724-9275
Shiri Graff van CreveldSchool of Oceanography, University of Washington, Seattle, WA, 98105, USA.ORCID https://orcid.org/0000-0002-3445-3046
Amichai ZafrinDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Assaf VardiDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0002-7079-0234

Funding

Institute for Environmental Sustainability (IES)Israel Science Foundation 749/24
6 · The paper itself

Abstract

Climate-driven marine heatwaves (HW) are extreme, large-scale events characterized by elevated ocean temperatures lasting from days to months. Despite their importance, little is known about the molecular mechanisms of algal response to marine HW. Recent studies suggest that metacaspases play an important role in thermotolerance. Metacaspases are cysteine proteases structurally similar to caspases that are best known for their role in programmed cell death. In order to study the role of metacaspases in diatoms' thermotolerance, we exposed the model diatom Phaeodactylum tricornutum and mutants in the metacaspase genes to a 72-h HW followed by a recovery phase that enables capturing the mechanisms underpinning acclimation. PtMCA-III triple mutants exhibited increased sensitivity to the HW treatment, including induction of cell death that peaked days after returning to initial temperatures. We revealed that HW treatment led to accumulation of H

Indexed as

Aquatic OrganismsCaspasesDiatomsHeat-Shock ResponseAntioxidantsCell DeathHot TemperatureHydrogen PeroxideMutationOxidative StressAntioxidantsCaspasesHydrogen PeroxideDiatomsmarine heatwavesmetacaspaseoxidative stressthermotolerance

Identifiers

PMID41724713
PMCPMC13103415

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.