Evidence map›Paper›PMID 41724676›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Perilesional white matter gradients reveal microstructural differences in cerebral amyloid angiopathy versus Alzheimer's disease.

Xinyuan Yang, Junfang Zhang, Fang Xie, Yan Wang, Yingting Zheng, Qi Huang, Wenjing Wang, Wei Xu, Yihui Guan, Jun Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinyuan YangDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junfang ZhangDepartment of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fang XieDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Yan WangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Yingting ZhengDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi HuangDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Wenjing WangDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei XuDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yihui GuanDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jun LiuDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yulei DengDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Magdy H SelimStroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Xiaomeng XuDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Binyin LiDepartment of Neurology & Institute of Neurology, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-7903-2149

Funding

National Key Research and Development Program of China, and Scientific and Technological Innovation 2022ZD0213800National Natural Science Foundation of China 82271441National Natural Science Foundation of China 82571604
6 · The paper itself

Abstract

introductionWhite matter hyperintensities (WMHs) are common in both Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), yet their spatial tissue characteristics and microstructural differences remain poorly understood.

methodsWe analyzed 351 participants: 184 amyloid beta (Aβ)-positive AD and mild cognitive impairment (MCI), 139 Aβ-negative cognitively normal controls (CN), and 28 probable CAA. Multimodal magnetic resonance imaging metrics were used to estimate spatial gradient parameters for periventricular WMHs (pWMH) and deep WMHs (dWMH).

resultsCAA demonstrated distinctive free-water fraction (FWF), fractional anisotropy (FA), mean diffusivity (MD), and plasma volume within pWMH, as well as spatial gradient parameters of pWMH. These pWMH spatial gradient parameters produced area under the curve (AUC) values of 0.71 (FWF), 0.72 (MD), and 0.79 (FA) when distinguishing CAA from AD/MCI. We retested a subset of the cohort after 1 to 2 years (AUCs: FWF = 0.89, MD = 0.79, FA = 0.85). DISCUSSION: Spatial gradient parameters reflect disease-specific microstructural and vascular changes, providing insights into CAA and AD pathology.

Indexed as

Alzheimer DiseaseBrainCerebral Amyloid AngiopathyWhite MatterAgedAged, 80 and overAnisotropyCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMalealzheimer's diseasecerebral amyloid angiopathynormal‐appearing white matterspatial gradientswhite matter hyperintensities

Identifiers

PMID41724676
PMCPMC12927939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.