Evidence map›Paper›PMID 41724675›Full record

ArticleAging cell2026

Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging.

Namki Hong, Sang Wouk Cho, Alan A Cohen, Russell T Hepple, Paul M Coen, Bumsoo Ahn, Anne B Newman, Stephen B Kritchesky, Paul J Laurenti, Warren S Browner and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Namki HongSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Sang Wouk ChoDepartment of Biomedical Systems Informatics, Yonsei University, College of Medicine, Seoul, South Korea.
Alan A CohenDepartment of Environmental Health Sciences, Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, NY, USA.ORCID 0000-0003-4113-3988
Russell T HeppleDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Paul M CoenAdventHealth, Translational Research Institute, Orlando, FL, USA.ORCID 0000-0002-2805-2115
Bumsoo AhnDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-2743-7099
Anne B NewmanDepartment of Epidemiology, School of Public Health, University of Pittsburgh, PA, USA.ORCID 0000-0002-0106-1150
Stephen B KritcheskyDepartment of Internal Medicine, Section on Gerontology & Geriatric Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Paul J LaurentiDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Warren S BrownerSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.ORCID 0000-0001-8808-260X

Funding

National institute of Aging R01AG059416d
6 · The paper itself

Abstract

Entropy may play an underappreciated role in human aging, such as in skeletal muscle functional declines. Histologically, muscle appears increasingly disorganized with aging, with greater fiber size variability and fiber-type grouping. We tested the hypothesis that entropy is associated with reduced physical performance and muscle function, independent of muscle mass. We quantified a homeostatic dysregulation index of muscle (HDI

Indexed as

AgingEntropyMuscle Fibers, SkeletalAgedAged, 80 and overFemaleHumansMaleMuscle, Skeletalagingcomputer‐assistedentropyimage processingmobility limitationmuscles

Identifiers

PMID41724675
PMCPMC12927989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.