ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
introductionAccelerated long-term forgetting (ALF) may represent one of the earliest cognitive changes in Alzheimer's disease (AD). However, whether ALF emerges in the preclinical stage of autosomal-dominant AD (ADAD) is unclear, and its underlying mechanisms are poorly understood.
methodsWe assessed ALF via long-term memory testing, sleep physiology via overnight electroencephalography, and AD neuropathology burden via positron emission tomography in 28 non-demented PSEN1 E280A mutation carriers and 24 healthy non-carriers from a Colombian ADAD kindred.
resultsNon-demented carriers exhibited ALF despite having intact short-term memory. They also demonstrated isolated reduction in parietal sleep spindle (SS) power, whereas other aspects of sleep remained intact. Reduced parietal SS power was associated with both ALF and greater tau burden in the precuneus. DISCUSSION: ALF is among the earliest cognitive changes in preclinical ADAD, and the specific disruption of parietal SS power may be a key neurophysiologic mechanism linking early tau accumulation to ALF.
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