ArticleClinical lymphoma, myeloma & leukemia2026
Analysis of Social Drivers of Health, Race, and Ethnicity With Survival in Myeloma Patients.
Article in Clinical lymphoma, myeloma & leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDespite the introduction of novel antimyeloma therapies, Black and Hispanic individuals with multiple myeloma (MM) often experience worse survival outcomes than White counterparts, influenced not only by disease-related factors but by nonbiological factors such as social drivers of health (SDOH). We evaluated the impact of the Area Deprivation Index (ADI), a neighborhood-level SDOH measure, on survival in patients with MM receiving standardized, high-quality care.
methodsWe conducted a retrospective cohort study of 476 patients with newly diagnosed MM treated at The University of Texas MD Anderson Cancer Center from January 2010 to December 2017. Progression-free survival (PFS) and overall survival (OS) were the primary outcomes.
resultsOf the cohort, 27% self-identified as Black, 18% as Hispanic, and 55% as White; 54% were male. Black and Hispanic patients were younger at diagnosis (median age 58.3 years) compared to White patients (63.1 years). White patients resided in neighborhoods with lower mean ADI values (51.7 ± 23.3) than Black (61.2 ± 21.5) and Hispanic (63.7 ± 19.3) patients, indicating lower deprivation. Higher ADI correlated with more advanced disease stage but no other clinical features. PFS and OS did not differ significantly by ADI quartile or race/ethnicity groups. Survival outcomes remained consistent in both race/ethnicity- and ADI-stratified analyses.
conclusionsAlthough Black and Hispanic patients lived in areas of greater deprivation, survival outcomes were comparable across ADI and racial/ethnic groups. These findings suggest that access to standardized, high-quality care may mitigate disparities in outcomes driven by SDOH. Replication in other care settings is warranted.
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