ReviewCurrent opinion in neurobiology2026
Sexual dimorphism in the nervous system: Three principles from the nematode C.elegans.
Review in Current opinion in neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Recent interest in the neurobiology of the C. elegans male has driven exciting progress in understanding sexual dimorphism in the nervous system of this important model system. From these studies, a framework emerges in which the effects of biological sex fall into three overlapping categories. First, sex modulates developmental programs of cell lineage, neurogenesis, and cell fate specification to generate neuronal classes and structures that appear only in one sex. Second, sex modifies synaptic connectivity to alter the topology of neural circuits. Third, sex acts as a dimension of internal state, developmentally and dynamically modulating the physiology of sex-shared neurons and circuits. Together, these effects program sex-specific behaviors, tune sex-shared behaviors, and implement sexually dimorphic behavioral plasticity. Importantly, C. elegans offers the opportunity to understand these effects with uniquely high mechanistic resolution. Although mechanisms of sex determination differ markedly by species, these principles are likely conserved across evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.