ReviewTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy2026
Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism.
Review in Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium-sensing receptor sensitivity and reducing parathyroid hormone secretion. Upacicalcet is a novel intravenous calcimimetic that was specifically developed for hemodialysis patients. It is efficiently removed by hemodialysis, does not undergo hepatic metabolism, and has minimal potential for drug-drug interactions. Clinical studies have shown that upacicalcet effectively lowers serum intact parathyroid hormone and improves associated biochemical markers such as fibroblast growth factor-23 and bone turnover indices. It demonstrates a low incidence of gastrointestinal symptoms and hypocalcemia. Upacicalcet achieves sustained biochemical control with good tolerability in long-term use. These features suggest that upacicalcet is a safe and ideal option for the long-term management of SHPT in patients undergoing hemodialysis.
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