Evidence map›Paper›PMID 41723910›Full record

ArticleThe journal of nutrition, health & aging2026

Distinct associations between body mass index and polyunsaturated fatty acids in dementia with Lewy Bodies and Alzheimer's disease.

Nicolás Castellanos-Perilla, Miguel Germán Borda, Joyce Ruifen Chong, Diego Alejandro Tovar-Rios, Alberto Jaramillo-Jimenez, Rolf K Berge, George E Barreto, Dag Aarsland, Audun Osland Vik-M

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Article in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nicolás Castellanos-PerillaDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Electronic address: nicolas.castellanos.perilla@sus.no.
Miguel Germán BordaCentre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Department of Neurology, Clínica Universidad de Navarra, Pamplona, Spain.
Joyce Ruifen ChongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Memory, Aging and Cognition Centre, National University Health Systems, Singapore, Singapore; Centre for Healthy Brain Ageing, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Diego Alejandro Tovar-RiosCentre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; L-BioStat, KU Leuven, Leuven, Belgium; Grupo de Investigación en Estadística Aplicada - INFERIR, Facultad de Ingeniería, Universidad del Valle, Santiago de Cali, Valle del Cauca, Colombia; Prevención y Control de la Enfermedad Crónica - PRECEC, Facultad de Salud, Universidad del Valle, Santiago de Cali, Valle del Cauca, Colombia.
Alberto Jaramillo-JimenezCentre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Grupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Rolf K BergeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
George E BarretoDepartment of Biological Sciences, University of Limerick, Limerick, Ireland.
Dag AarslandCentre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Centre for Healthy Brain Ageing, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Audun Osland Vik-MDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to assess the association between body mass index and polyunsaturated fatty acids to determine potential links and metabolic differences between Alzheimer's disease and dementia with Lewy bodies.

methodsWe performed a cross-sectional study of enrolment data with 133 patients with mild AD (n = 75) and DLB (n = 58) from a Norwegian cohort study. We used linear regression models adjusting for age, sex, and diagnosis to explore the association between PUFA concentrations and BMI estimates.

resultsIn DLB patients, BMI was positively associated with downstream omega-6 PUFA, including gamma-linolenic acid (GLA; β = 0.285, p = 0.012), arachidonic acid (AA; β = 0.320, p = 0.005), and adrenic acid (β = 0.303, p = 0.005). BMI was also related to increased Δ6-desaturase n-6 activity (β = 0.383, p = 0.002) and Δ6-desaturase n-3 activity (β = 0.335, p = 0.011), along with reduced elongase n-6 (β = -0.396, p = 0.002) and elongase n-3 (β = -0.376, p = 0.004), suggesting increased fatty acid turnover. No significant associations were found in the AD group.

conclusionsBMI in DLB patients was positively associated with elevated downstream omega-6 metabolites and desaturase and elongase activity, compatible with higher fatty‑acid turnover and systemic inflammatory state hypothesized in DLB. These findings highlight the distinct metabolic alterations across dementia subtypes that are relevant for personalized nutritional strategies in dementia care.

Indexed as

Alzheimer DiseaseBody Mass IndexFatty Acids, UnsaturatedLewy Body DiseaseAgedAged, 80 and overCohort StudiesCross-Sectional StudiesFatty Acid DesaturasesFatty Acids, Omega-6FemaleHumansMaleNorwayFatty Acid DesaturasesFatty Acids, Omega-6Fatty Acids, UnsaturatedDementianeurodegenerative diseasesnutritionpolyunsaturated fatty acids

Identifiers

PMID41723910
PMCPMC12945632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.