Evidence map›Paper›PMID 41723788›Full record

ReviewDocumenta ophthalmologica. Advances in ophthalmology2026

ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli.

Jan Kremers, Mirella T S Barboni, Andrew J Zele, Beatrix Feigl, J Jason McAnany, Anthony G Robson, Balázs Vince Nagy, Neil Parry, Omar A Mahroo, Cord Huchzermeyer

Erratum issuedAbstract readReview
In one paragraph

Review in Documenta ophthalmologica. Advances in ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jan KremersSection for Retinal Physiology, Department of Ophthalmology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany. jan.kremers@uk-erlangen.de.
Mirella T S BarboniDepartment of Ophthalmology, Semmelweis University, Budapest, Hungary.
Andrew J ZeleCentre for Vision and Eye Research, Queensland University of Technology, Brisbane, Australia.
Beatrix FeiglCentre for Vision and Eye Research, Queensland University of Technology, Brisbane, Australia.
J Jason McAnanyDepartment of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, USA.
Anthony G RobsonMoorfields Eye Hospital, London, UK.
Balázs Vince NagyDepartment of Mechatronics, Optics and Mechanical Engineering Informatics, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Budapest, Hungary.
Neil ParryVision Science Centre, Manchester Royal Eye Hospital, Manchester, UK.
Omar A MahrooMoorfields Eye Hospital, London, UK.
Cord HuchzermeyerSection for Retinal Physiology, Department of Ophthalmology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany.

Funding

The German Federal Ministry for Education and Research (Bundesministerium für Bildung und Forschung, BMBF) 01EW2101
6 · The paper itself

Abstract

The International Society for Clinical Electrophysiology of Vision (ISCEV) Standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the full-field ERG Standard, namely the ERG responses to silent substitution stimuli that are directed at the response modulation of single photoreceptor types. The method can be used to detect selective defects in distinct photoreceptor types and post-receptoral retinal pathways. This document, based on existing literature, provides protocols for recording and analyzing the responses to a single class of photoreceptor directed stimuli. For each photoreceptor type (rods, L-, M- and S-cones), optimal luminance conditions and temporal frequencies for Ganzfeld recordings are provided. The exact stimulus conditions depend on the spectral properties of the stimulator. An accompanying technical report describes an app that is meant to provide support in calculating stimuli for individual stimulators.

Indexed as

ElectroretinographyPhotoreceptor Cells, VertebrateHumansPhotic StimulationElectroretinography (ERG)PhotoreceptorsSilent substitution

Identifiers

PMID41723788
PMCPMC13083440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.