Evidence map›Paper›PMID 41723725›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026

The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease.

Mohamed Reda Fazazi, Manu Rangachari

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mohamed Reda FazaziDepartment of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec City, Canada.
Manu RangachariDepartment of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec City, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) involve complex interactions between local tissues and the immune system. Here, we highlight the immunological parallels between the central nervous system (CNS) meninges and the synovial joint, two sites traditionally considered immune-privileged. Both harbor resident immune cells and lymphatic vessels and support the formation of tertiary lymphoid organs (TLO) during chronic inflammation. In MS, meningeal TLO contributes to cortical grey matter damage, while in RA, synovial TLO drives joint destruction. T peripheral helper (Tph) cells, a subset of CD4

Indexed as

Arthritis, RheumatoidAutoimmune DiseasesMeningesSynovial MembraneAnimalsB-LymphocytesHumansMultiple SclerosisTertiary Lymphoid Structuresautoimmunitymeningesmultiple sclerosis (MS)rheumatoid arthritis (RA)synovial jointtertiary lymphoid organs (TLO)T peripheral helper cells (Tph)

Identifiers

PMID41723725
PMCPMC12925387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.