Evidence map›Paper›PMID 41723719›Full record

Trial reportMolecular nutrition & food research2026

The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data.

Sara Brehmer-Henkel, Christina Diekmann, Marit Eickeler, Ronja Maris, Christina Kopp, Martin Coenen, Robert Németh, Birgit Stoffel-Wagner, Nadine Sus, Jan Frank and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara Brehmer-HenkelInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Christina DiekmannInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Marit EickelerInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Ronja MarisInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Christina KoppInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Martin CoenenClinical Study Core Unit, Study Center and Central Laboratory Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Robert NémethInstitute of Medical Biometry, Informatics and Epidemiology, Venusberg-Campus 1, University Hospital Bonn, Bonn, Germany.
Birgit Stoffel-WagnerClinical Study Core Unit, Study Center and Central Laboratory Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Nadine SusDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, Hohenheim University, Stuttgart, Germany.
Jan FrankDepartment of Food Biofunctionality (140b), Institute of Nutritional Sciences, Hohenheim University, Stuttgart, Germany.
Sarah EgertInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.

Funding

AQUANOVA AG
6 · The paper itself

Abstract

Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t

Indexed as

FlavonoidsPropiophenonesAdultArea Under CurveBiological AvailabilityCross-Over StudiesDose-Response Relationship, DrugFemaleHumansMaleMicellesYoung AdultFlavonoidsMicellesPropiophenonesxanthohumolbioactivitybioavailabilityblood pressureenergy expenditureflavonoidxanthohumol

Identifiers

PMID41723719
PMCPMC12925386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.