Evidence map›Paper›PMID 41723445›Full record

ArticleBMC biotechnology2026

Formulation and evaluation of hydrogel based on Brazilian propolis ethanol extract for promoting diabetic wound healing.

Huanglin Huo, Zhenhua Zhou, Rongxiang Guo, Jinyi Zhang, Menghan Li, Huicong Zeng, Dongyu Zhao, Roman P Terekhov, Peng Jiang, Qian Zhou and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Huanglin Huo *The First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Zhenhua Zhou *The First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Rongxiang GuoMOE Key Laboratory of Tumor Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Jinyi ZhangThe First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Menghan LiThe First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Huicong ZengThe First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Dongyu ZhaoThe First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Roman P TerekhovNelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University, Trubetskaya Str. 8/2, Moscow, 119991, Russia.
Peng JiangInstitute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, 610052, China. peng.jiang@ibt.pumc.edu.cn.
Qian ZhouMOE Key Laboratory of Tumor Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China. zhouqian_whu@163.com.
Bo LiThe First Affiliated Hospital of Guangdong Pharmaceutical University, MOE Key Laboratory of Glucolipid Metabolic Disorder, Guangdong Provincial TCM Key Laboratory for Metabolic Diseases, Traditional Chinese Medicine Research Institute (Guangdong Provincial Research Center of Integration of Traditional Chinese Medicine and Western Medicine in Metabolic Diseases), Guangdong Pharmaceutical University, Guangzhou, 510006, China. bo.li.dream@gmail.com.

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515030238Guangzhou Basic and Applied Basic Research Foundation 2025A04J5238Guangzhou Science and Technology program City-University Joint Funding Project 2024A03J0596Natural Science Foundation of China 32370966Project of Guangdong Provincial Health Commission 0720240238Science and Technology Program of Sichuan 2022YFS0010Traditional Chinese Medicine of Guangdong Province 20244044, 20241171
6 · The paper itself

Abstract

Diabetes wounds represent a significant clinical challenge, primarily attributed to their complex microenvironment characterized by persistent inflammation, heightened infection susceptibility, and impaired angiogenesis. To address these interconnected challenges, a multifunctional hydrogel dressing (designated EEP/PS) was constructed using pullulan, Brazilian propolis ethanolic extract, and polyvinyl alcohol. This biomaterial exhibits an interconnected porous structure, suitable mechanical properties, tissue adhesion, remarkable thermal stability, excellent sustained-release and swelling capacity. Notably, EEP/PS shows potent antioxidant capability and significantly enhances cell migration in hydrogen peroxide-induced oxidative injury models. Furthermore, the hydrogel downregulates the expression and secretion of key pro-inflammatory cytokines in LPS-stimulated macrophages, including tumor necrosis factor-α, interleukin-6, and interleu-kin-1β. The hydrogel also exhibits broad-spectrum antibacterial efficacy against common wound pathogens Escherichia coli and Staphylococcus aureus. In a diabetic rat model, EEP/PS accelerated wound closure by synergistically promoting reepithelialization, collagen deposition, angiogenesis while mitigating local inflammation. Additionally, EEP/PS exhibits an excellent hemostasis capacity and bio-compatibility, critical for clinical translation. Collectively, these findings highlight the translational potential of EEP/PS as a multifunctional biomaterial for diabetic wound care.

Indexed as

Anti-Bacterial AgentsDiabetes Mellitus, ExperimentalHydrogelsPropolisWound HealingAnimalsAntioxidantsBrazilEscherichia coliEthanolMaleMiceRatsRats, Sprague-DawleyStaphylococcus aureusAnti-Bacterial AgentsAntioxidantsEthanolHydrogelsPropolisAntibacterialBrazilian propolisDiabetic woundsHydrogelInflammation

Identifiers

PMID41723445
PMCPMC13032371

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.