ArticleRespiratory research2026
Association between nutritional status and clinical characteristics in nontuberculous mycobacterial pulmonary disease: preliminary results from the NTM-KOREA cohort.
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03934034 (A Prospective Registry For Patients With Non-Tuberculous Mycobacterial), which is not on this map. Cited by 2 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Registry For Patients With Non-Tuberculous Mycobacterial (NTM) Pulmonary Disease in Korea.
Who cites it
2 citing papers in PubMed.
- High prevalence of malnutrition and sarcopenia in patients with NTM pulmonary disease: results from an Italian prospective multicentre study.Respiratory research · 2026Observational
- Early treatment interruption and nutritional status as predictors of mortality in Mycobacterium avium complex pulmonary disease.PloS one · 2026Article
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Authors and funding
21 authors.
Funding
Abstract
backgroundEvidence on the association between nutritional status and clinical characteristics in nontuberculous mycobacterial pulmonary disease (NTM-PD) remains limited. We investigated this association and its impact on longitudinal outcomes in a nationwide cohort.
methodsWe analysed 627 patients from the NTM-KOREA cohort study who had initiated antibiotic therapy for NTM-PD. Baseline nutritional status was assessed using the Prognostic Nutritional Index (PNI) and Mini Nutritional Assessment Short Form (MNA-SF) tools. Clinical characteristics, physical function, and health-related quality of life (HRQOL) using Quality of Life Questionnaire–Bronchiectasis (QOL-B) were evaluated. Longitudinal analyses were performed at 6 and 12 months after therapy initiation.
resultsIn the baseline anlysis group (N = 627; mean age: 64.3 ± 9.7 years; females: 73.7%), 112 (17.9%) patients were classified as malnourished according to the PNI, and MNA-SF identified 319 (50.9%) patients at risk and 40 (6.4%) as malnourished. Multivariable regression analysis revealed that the PNI-defined malnutrition group was associated with increased odds (odds ratio [95% confidence interval]) of having dyspnoea (2.37 [1.34 to 4.11]), acid-fast bacilli smear positivity (2.26 [1.44 to 3.57]), and cavitary lesions (2.03 [1.25 to 3.37]). This group was also associated with higher BACES (body mass index, age, cavity, erythrocyte sedimentation rate, and sex) scores (β = 0.9), shorter 6-min walking distance (β = -42.1 m), and lower QOL-B scores across physical functioning (β = -10.6), role functioning (β = -7.4), and respiratory symptoms (β = -8.0) (all P < 0.001). In the longitudinal anlysis group (n = 457), poor nutritional status reduced the likelihood of 6-month respiratory symptom improvement (0.44 [0.22 to 0.87]). In the treatment outcome analysis group (n = 119), MNA-defined malnutrition was significantly associated with an increased risk of premature treatment discontinuation within 1 year (26.41 [2.82 to 633.89]).
conclusionsBaseline nutritional status was closely associated with disease severity and HRQOL in NTM-PD. Preliminary longitudinal data suggested that malnutrition may negatively impact symptomatic improvement and treatment adherence, highlighting the need for routine nutritional assessment.
trial registrationClinicalTrials.gov identifier NCT03934034, Registration date May 1, 2019.
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