SynthesisBMC cancer2026
Dietary inflammatory index and risk of major digestive tract cancers: a GRADE-assessed systematic review and dose-response meta-analysis.
Synthesis in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dietary inflammatory potential and oral cancer risk: a meta-analysis of observational studies.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsGastrointestinal (GI) cancers are an umbrella term for a group of malignant tumors that affect the digestive system. This systematic review and meta-analysis aimed to evaluate the association between the Dietary Inflammatory Index (DII) and the risk of GI cancers by synthesizing evidence from observational studies.
methodsPubMed, Scopus, and Web of Science were searched using terms related to GI cancers and DII. A total of 52 observational studies (18 cohort, 34 case-control) were analyzed. Random or fixed effects meta-analyses were conducted to pool risk ratio (RR) for the highest vs. the lowest DII categories, with dose-response analyses performed where feasible. Quality was assessed via the Risk of Bias in Non-randomised Studies of Exposures tool. Evidence certainty was graded using the GRADE framework.
resultsHigher DII scores (pro-inflammatory diets) were significantly associated with increased risks of colorectal (RR 1.16, 95% confidence interval [CI] 1.04–1.29), colon (RR 1.12, 95% CI 1.11–1.33), and rectal cancers (RR 1.25, 95% CI 1.07–1.47) in cohort studies. No significant associations were found for gastric or pancreatic cancers in cohort studies. Case-control studies showed stronger associations for oral (RR 2.46), esophageal (RR 2.63), and pancreatic cancers (RR 2.57).
conclusionThe findings highlight the importance of dietary modifications to reduce inflammation for cancer prevention. Further prospective studies are needed to clarify causal relationships and refine dietary recommendations. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42023484691.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.