ArticleBMC infectious diseases2026
Active surveillance of cytomegalovirus and pulmonary aspergillosis in critically ill patients with COVID-19: risk assessment of high-dose steroids.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpportunistic infections such as cytomegalovirus (CMV) and COVID-19-associated pulmonary aspergillosis (CAPA) pose major risks in critically ill COVID-19 patients, particularly those receiving high-dose corticosteroids.
methodsWe conducted weekly active surveillance for CMV and Aspergillus in 210 ICU-admitted patients with severe COVID-19. Incidence, timing, and risk factors were assessed, with a focus on corticosteroid dose. Inverse probability of treatment weighting (IPTW)-adjusted logistic regression and Kaplan–Meier survival analyses were applied.
resultsCMV DNAemia (≥ 1000 copies/mL) occurred in 29.0% of patients, peaking during weeks 3–4. CAPA (possible + probable) occurred in 14.3% and peaked earlier, within the first two weeks. High-dose corticosteroid use was associated with significantly increased risks of CMV DNAemia (aOR 5.34; 95% CI, 2.69–10.58) and CAPA (aOR 2.28; 95% CI, 1.22–4.25).
conclusionCMV and CAPA occurred in distinct temporal patterns, with CMV reactivation peaking later in the ICU course. High-dose corticosteroids significantly increased the risk of both infections, underscoring the need for tailored surveillance strategies during intensive care. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.