Evidence map›Paper›PMID 41723365›Full record

ArticleBMC nephrology2026

When childhood anomalies grow up: adult-onset discovery of multicystic dysplastic kidney, a case report.

Dina R Gonzalez-Hernandez, Haya Al Suradi, Nickolas Coombs, Christina L Tamargo, Mohamad Hanouneh, C Elena Cervantes

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Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dina R Gonzalez-HernandezDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. dgonza45@jh.edu.
Haya Al SuradiDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nickolas CoombsDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christina L TamargoDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mohamad HanounehDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
C Elena CervantesDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMulticystic dysplastic kidney (MCDK) is a congenital condition where noncommunicating cysts replace normal renal parenchyma, affecting about 1 in 4,300 live births. Unilateral MCDK is often asymptomatic, it may cause flank pain, hematuria, or hypertension. CASE DESCRIPTION: A 40-year-old male with history of hypertension since age 20 was referred to our clinic for evaluation of cystic kidney. He had no family history of kidney disease. His blood pressure was 145/85 mmHg. Serum creatinine was 0.8 mg/dL. Urinalysis did not show hematuria or proteinuria. Renal ultrasound showed an enlarged right kidney (15.4 cm) and smaller left kidney (9.8 cm) with lower pole cysts. Abdominal MRI confirmed numerous noncommunicating cysts with absent normal parenchyma in the left kidney, consistent with MCDK (Fig. 1). The right kidney and liver were normal. Genetic testing was negative for PKD1 and PKD2, and other less common variants of cystic kidney disease. The patient was managed conservatively with blood pressure control and monitoring of kidney function and proteinuria. DISCUSSION: MCDK is usually diagnosed by ultrasound or MRI. Asymptomatic unilateral cases are managed conservatively; nephrectomy is reserved for symptomatic or enlarging kidneys. Bilateral MCDK is typically fatal due to kidney failure and pulmonary hypoplasia. Unilateral cases have a good prognosis, with many undergoing spontaneous involution and compensatory hypertrophy of the contralateral kidney. Long-term follow-up includes monitoring for hypertension, malignancy, and proteinuria. Rarely, MCDK may mimic atypical autosomal dominant polycystic kidney disease. Early diagnosis and tailored care are key for favorable outcomes.

conclusionUnilateral MCDK is rare but generally carries a good prognosis with conservative management and regular monitoring.

Indexed as

Multicystic Dysplastic KidneyAdultHumansMaleUltrasonographyCase reportMulticystic dysplastic kidney (MCDK)PrognosisUnilateral

Identifiers

PMID41723365
PMCPMC13032564

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