Evidence map›Paper›PMID 41723338›Full record

ReviewAnalytical and bioanalytical chemistry2026

Advances in spatial omics for the analysis of prostate cancer.

Junyi Xu, Dejiang Wang, Xiangjun Di, Yang Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junyi XuDepartment of Chemistry, Yale University, New Haven, CT, 06510, USA.
Dejiang WangDepartment of Pathology, Yale School of Medicine, New Haven, CT, 06510, USA.
Xiangjun DiDepartment of Pathology, Yale School of Medicine, New Haven, CT, 06510, USA.
Yang LiuDepartment of Pathology, Yale School of Medicine, New Haven, CT, 06510, USA. yang.liu.yl2224@yale.edu.

Funding

Spatially resolved multiomics profiling of microbes and their host tissueR35GM150838 · NIGMS · YALE UNIVERSITY · PI Yang Liu · 2023 to 2026
$1.7M
Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis"R01HL173271 · NHLBI · YALE UNIVERSITY · PI Yang Liu · 2024 to 2026
$1.4M
NHLBI NIH HHS R01 HL173271NHLBI NIH HHS R01HL173271NIGMS NIH HHS 1R35GM150838NIGMS NIH HHS R35 GM150838
6 · The paper itself

Abstract

Prostate cancer is one of the most common malignancies in men and is marked by extensive clinical and molecular heterogeneity. Although genomic and transcriptomic studies have revealed recurrent alterations and lineage plasticity, these approaches lack spatial resolution and therefore cannot capture the microenvironmental context that underpins tumor progression and therapeutic resistance. Spatial omics technologies have emerged as transformative tools by integrating high-dimensional molecular profiling with preserved tissue architecture. Advances in spatial transcriptomics, proteomics, epigenomics, and metabolomics now permit the mapping of gene expression, protein signaling, chromatin accessibility, modifications, and folding, along with metabolic gradients at cellular to subcellular resolution. Spatial analysis of prostate cancer has revealed key features of disease progression, including stromal remodeling, immune evasion, lipid metabolic rewiring, and therapy-resistant niches. This review highlights recent spatial omics technologies, their emerging integrative and clinical applications in prostate cancer, and the future challenges in standardization, data integration, and clinical translation.

Indexed as

MultiomicsProstatic NeoplasmsProteomicsSpatial TranscriptomicsEpigenomicsGenomicsHumansMaleMetabolomicsEpigenomicsProstate cancerProteomicsSpatial transcriptomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.