Evidence map›Paper›PMID 41723185›Full record

ArticleNature communications2026

VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement.

Somya Vats, Pedro Dionisio, Quentin Lemercier, Raphael Pineau, Ludivine Therreau, Joanna Lipecka, Béatrice Cholley, Jean-Baptiste Moog, Jose Wojnacki, Céline Keime and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Somya VatsUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France.
Pedro Dionisio *Multidisciplinary Institute of Ageing (MIA), University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0003-2756-1863
Quentin Lemercier *Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France.ORCID http://orcid.org/0000-0003-1938-2072
Raphael PineauINSERM U1242, Université de Rennes, Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France.ORCID http://orcid.org/0000-0002-0701-7302
Ludivine TherreauUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, PhenoBrain, Paris, France.
Joanna LipeckaNecker Proteomics, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris, France.ORCID http://orcid.org/0000-0003-0000-2666
Béatrice CholleyUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France.
Jean-Baptiste MoogUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France.
Jose WojnackiUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France.
Céline KeimeIGBMC, CNRS UMR 7104, Inserm U1258, Université de Strasbourg, Illkirch, France.ORCID http://orcid.org/0000-0001-7604-3814
Diana ZalaUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Dynamics of Neuronal Structure in Health and Disease, Paris, France.ORCID http://orcid.org/0000-0002-0052-8011
Philippe BunUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, NeurImag Core Facility, Paris, France.ORCID http://orcid.org/0000-0002-7975-1768
Sofia FreireMultidisciplinary Institute of Ageing (MIA), University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0009-0002-2316-1096
Neuza DominguesMultidisciplinary Institute of Ageing (MIA), University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0002-2073-412X
Lydia DanglotUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France.ORCID http://orcid.org/0000-0001-6190-6605
Ida Chiara GuerreraNecker Proteomics, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris, France.ORCID http://orcid.org/0000-0002-4832-6793
Cédric DelevoyeUniversité Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.ORCID http://orcid.org/0000-0002-3835-6649
Eric ChevetINSERM U1242, Université de Rennes, Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France.ORCID http://orcid.org/0000-0001-5855-4522
Nuno RaimundoMultidisciplinary Institute of Ageing (MIA), University of Coimbra, Coimbra, Portugal. nuno.raimundo@psu.edu.ORCID http://orcid.org/0000-0002-5988-9129
Thierry GalliUniversité Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, Paris, France. thierry.galli@inserm.fr.ORCID http://orcid.org/0000-0001-8514-7455

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-23-CE16-0035-01
6 · The paper itself

Abstract

Late endosomal secretion is an unconventional secretion mechanism that depends on the SNARE protein VAMP7. We previously showed that VAMP7 mediates the secretion of the ER protein Reticulon3. However, the functional relevance and molecular mechanism of this secretory pathway remain unclear. Here, we show that VAMP7 knockout cells exhibit impaired secretion of ER- and mitochondrial-derived proteins and signs of ER and mitochondrial stress. In addition, pharmacological induction of organellar stress enhances the VAMP7-dependent secretion. We assess the pathophysiological significance of this mechanism using a preclinical glioblastoma model. VAMP7 knockout glioblastoma cells implanted in male rat brain develop into more necrotic tumors with reduced macrophage infiltration compared to controls, suggesting that VAMP7-dependent late endosomal secretion contributes to the tumor microenvironment and affects macrophage infiltration. Together, our results support a model in which late endosomal secretion functions as an organelle quality-control and stress-communication mechanism, with particular relevance to cancer.

Indexed as

Endoplasmic ReticulumEndosomesGlioblastomaMacrophagesMitochondrial ProteinsR-SNARE ProteinsTumor MicroenvironmentAnimalsCell Line, TumorEndoplasmic Reticulum StressHumansMaleMitochondriaRatsMitochondrial ProteinsR-SNARE ProteinsVAMP7 protein, human

Identifiers

PMID41723185
PMCPMC13035943

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.