ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026
Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Pro-inflammatory markers interact with spontaneous theta oscillations to predict depression among adolescents.Brain, behavior, and immunity · 2026Article
- Gamma and beta power and the 1/f slope vary across a spectrum of depression severity.Translational psychiatry · 2026Article
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12 authors.
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Abstract
backgroundAdolescence is a sensitive period for the emergence and refinement of cortical rhythms, which are shaped by excitatory-inhibitory (E/I) neurotransmission. However, stress-related disruptions in E/I balance may contribute to major depressive disorder (MDD). The aperiodic components of neurophysiological signals-slope and offset-index E/I dynamics and broadband power, respectively. Although altered E/I balance has been implicated in MDD and neurodevelopment more broadly, the role of aperiodic activity in predicting recurrence among adolescents remains unclear.
methodsResting-state electroencephalography and structured stress interviews were acquired from adolescents (N = 148; ages 13-18 years) with current (n = 42) or remitted (n = 106) MDD. Aperiodic slope and offset were parameterized across anterior, central, and posterior electrode clusters. In remitted youths, Cox proportional hazards models tested slope-by-stress and offset-by-stress interactions predicting MDD recurrence over the subsequent 12 months.
resultsAdolescents with current MDD exhibited significantly flatter aperiodic slopes across anterior, central, and posterior clusters (range F
conclusionsThe aperiodic slope may function as a neurophysiological diathesis that amplifies stress-related risk for depression recurrence. Findings support a diathesis-stress model of adolescent MDD and highlight the aperiodic slope as a biomarker that may guide developmentally sensitive personalized prevention strategies.
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