Gene × environment interaction between latrophilin-3 (Lphn3 or Adgrl3) and developmental permethrin exposure in Sprague Dawley rats.

Charles V Vorhees, Adam L Fritz, Brooke M Gollaway, Michael T Williams

Abstract read

In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charles V VorheesUniversity of Cincinnati College of Medicine, Department of Pediatrics and Cincinnati Children's Hospital Medical Center, Division of Neurology, Cincinnati, OH 45229, USA. Electronic address: charles.vorhees@cchmc.org.

Adam L FritzUniversity of Cincinnati College of Medicine, Department of Pediatrics and Cincinnati Children's Hospital Medical Center, Division of Neurology, Cincinnati, OH 45229, USA. Electronic address: adam.fritz@cchmc.org.

Brooke M GollawayUniversity of Cincinnati College of Medicine, Department of Pediatrics and Cincinnati Children's Hospital Medical Center, Division of Neurology, Cincinnati, OH 45229, USA. Electronic address: brooke.gollaway@cchmc.org.

Michael T WilliamsUniversity of Cincinnati College of Medicine, Department of Pediatrics and Cincinnati Children's Hospital Medical Center, Division of Neurology, Cincinnati, OH 45229, USA. Electronic address: michael.williams@cchmc.org.

Funding

Gene-pesticide interactions and ADHDR01ES032270 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI VORHEES, CHARLES V, WILLIAMS, MICHAEL T · 2020 to 2024

$2.2M

NIEHS NIH HHS R01 ES032270

6 · The paper itself

Abstract

Attention deficit hyperactivity disorder (ADHD) occurs in 9.8% of U.S. children and has a large hereditary component arising from multiple gene variants. One of these is Latrophiln-3 (LPHN-3). Using CRISPR/Cas9 we deleted exon 3 in Sprague Dawley rats to create a global Lphn3 knockout (gKO). The gKO rats are hyperactive, startle hyper-reactive, impulsive, and have impaired working, spatial, and egocentric learning and memory. Permethrin (PRM) is a widely used pyrethroid insecticide. Acute exposure to PRM alters acoustic startle but its long-term effects from developmental exposure are unknown. The present experiment tested whether Lphn3 heterozygosity interacts with PRM developmental exposure to affect post exposure neurobehavior in rats. We used Lphn3

Indexed as

Gene-Environment InteractionInsecticidesPermethrinReceptors, G-Protein-CoupledReceptors, PeptideAnimalsFemaleMaleRatsRats, Sprague-DawleyReflex, StartleInsecticideslphn3 protein, ratPermethrinReceptors, G-Protein-CoupledReceptors, PeptideADGRL3Egocentric learningGene by environment interactionsImplicit memoryLatrophilin-3PermethrinReference memorySpatial learning

Identifiers

PMID41722825

DOI10.1016/j.ntt.2026.107587

PMCPMC13502706

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.