ArticleThe Journal of nutrition2026
Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults.
Article in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCirculating biomarkers are often used to infer nutrient intakes and overall nutrient status, but may not accurately reflect nutrient concentrations in specific tissues. Since direct measurement of human tissue nutrient concentrations is rarely feasible, researchers rely on biomarkers as proxies. Studies linking diet, circulating biomarkers, and tissue nutrient concentrations are needed to enhance biomarker interpretability.
objectivesWe sought to evaluate the interrelationships among dietary intakes, circulating biomarkers, and human brain tissue stores of vitamin D and vitamin K, two nutrients implicated in cognitive health.
methodsBrain 25-hydroxyvitamin D
resultsWhen based on the most recent FFQ, vitamin D or vitamin K intakes were not associated with plasma or brain concentrations of their respective metabolites. However, when averaged across all available FFQs, total vitamin D intake was positively associated with plasma and brain 25(OH)D
conclusionsRepeated dietary assessments strengthened the associations for vitamin D, supporting the use of circulating 25(OH)D
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