Evidence map›Paper›PMID 41722511›Full record

ArticleRedox biology2026

ROS disrupt COP9 signalosome-mediated ABCA1 protection and trigger its ubiquitination and degradation by cullin3 inhibiting cholesterol efflux and promoting foam cell formation in response to GPCR agonists.

Suresh Govatati, Chandra Sekhar Yadavalli, James G Traylor, A Wayne Orr, Gadiparthi N Rao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suresh GovatatiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Chandra Sekhar YadavalliDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
James G TraylorDepartment of Pathology, Louisiana State University Health Science Center, Shreveport, LA, 71103, USA.
A Wayne OrrDepartment of Pathology, Louisiana State University Health Science Center, Shreveport, LA, 71103, USA.
Gadiparthi N RaoDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. Electronic address: rgadipar@uthsc.edu.

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Vesna Tesic · 2018 to 2026
$23.6M
Nck Adaptor Proteins in Atherogenic Endothelial ActivationR01HL133497 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2016 to 2024
$3.8M
EphA2 regulation of atherosclerotic smooth muscle phenotypeR01HL173972 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Anthony Wayne Orr · 2024 to 2026
$2.1M
GRP78 signaling and retinal angiogenesisR01EY034425 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GADIPARTHI N RAO · 2023 to 2026
$2.0M
NEI NIH HHS R01 EY034425NHLBI NIH HHS R01 HL133497NHLBI NIH HHS R01 HL173972NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

In this study, we investigated the intricate mechanisms underlying thrombin and Ang II-induced depletion of ABCA1. Under basal conditions, the COP9 signalosome interacts with ABCA1 as a whole complex rather than as individual subunits. In the presence of GPCR-agonists, thrombin or angiotensin II (Ang II), ABCA1 was phosphorylated and dissociated from COP9 signalosome, paving the way for its cullin3-mediated ubiquitination and degradation. Furthermore, forced expression of CSN5, the catalytic core subunit of the COP9 signalosome, inhibited thrombin or Ang II-induced ubiquitination and degradation of ABCA1, thereby restoring cholesterol efflux and suppressing foam cell formation. In addition, xanthine oxidase-dependent H

Indexed as

ATP Binding Cassette Transporter 1CholesterolCOP9 Signalosome ComplexCullin ProteinsFoam CellsReactive Oxygen SpeciesReceptors, G-Protein-CoupledAngiotensin IIAnimalsHumansMiceProteolysisSignal TransductionThrombinUbiquitinationABCA1 protein, humanAngiotensin IIATP Binding Cassette Transporter 1CholesterolCOP9 Signalosome ComplexCUL3 protein, humanCullin ProteinsReactive Oxygen SpeciesReceptors, G-Protein-CoupledThrombinABCA1Cholesterol effluxCOP9 signalosomecullin3Foam cellGPCRH(2)O(2)

Identifiers

PMID41722511
PMCPMC12945531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.