ArticleJournal of cancer survivorship : research and practice2026
Understanding the lived experience of colorectal cancer: a qualitative study of patient and clinician perspectives.
Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
purposeTo understand the lived experience of patients with non-metastatic (NM-CRC) and metastatic colorectal cancer (M-CRC) by identifying the signs, symptoms, and impacts they face throughout the disease course and treatment.
methodsAn international, non-interventional, qualitative interview study was conducted in the US, UK, Germany, and Japan. Six clinicians specializing in CRC were interviewed to inform disease symptomatic features, management, and clinically relevant concepts. Subsequently, 40 adult patients with NM-CRC (n = 19) or M-CRC (n = 21) participated in individual, semi-structured online concept elicitation interviews. Interviews were audio-recorded, transcribed, translated if needed, de-identified, and analyzed thematically using qualitative software.
resultsTiredness/fatigue, blood in stool, rectal bleeding, diarrhea, abdominal pain, abdominal cramping, constipation, and bloating were among the most frequently reported signs/symptoms of CRC. Many symptoms and impacts, including tiredness/fatigue, skin problems, nausea, hair loss, and numbness/tingling, were attributed to treatments like surgery, chemotherapy, and stoma presence. Daily life impacts included changes in physical abilities, social functioning, emotions, finances, and overall quality of life. A conceptual model of CRC signs/symptoms and impacts was developed based on clinician insights and refined based on patient interviews.
conclusionsThe study documented the disease and treatment experience of patients with CRC. Some differences were observed between the experiences of patients with M-CRC and NM-CRC; however, fatigue, bowel-related issues, and abdominal pain were consistently identified as prevalent and bothersome symptoms. IMPLICATIONS FOR CANCER SURVIVORS: Understanding the most bothersome CRC symptoms, impacts, and treatment side effects is essential for developing effective support programmes and potentially improving treatment approaches to enhance the quality of life for CRC survivors.
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