ArticleInternational ophthalmology2026
Comparison of different antibiotic prophylaxis regimens for the prevention of endophthalmitis after penetrating keratoplasty.
Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Therapeutic penetrating keratoplasty for recalcitrant microbial keratitis: An update.World journal of transplantation · 2026Review
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4 authors.
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Abstract
objectivesTo investigate the incidence of endophthalmitis following penetrating keratoplasty (PKP) and compare the effectiveness of different antibiotic regimens during the perioperative period.
methodsA retrospective cohort study was conducted involving 3706 patients who underwent PKP at Zhongshan Ophthalmic Center between 2012 and 2021. The preventive effects of intraoperative intraoperative local antibiotic injection, preoperative intravenous antibiotic administration, and the combination of both were evaluated. Logistic regression and survival analyses were performed to compare differences in endophthalmitis incidence among the different antibiotic prophylaxis groups.
resultsPostoperative endophthalmitis occurred in 15 of 3706 patients (0.40% incidence). Among 419 patients with underlying infectious corneal disease, 12 developed postoperative endophthalmitis (2.86% incidence). Among 3287 patients with non-infectious corneal diseases, 3 developed postoperative endophthalmitis (0.09% incidence; OR: 32.28, 95% CI 9.07-114.85). For patients with primary non-infectious corneal disease, no statistically significant difference was observed between the intraoperative intraoperative local antibiotic injection, group and the combined antibiotic administration group (P = 0.079).
conclusionThe primary corneal disease is a key risk factor for endophthalmitis after PKP. For non-infectious keratopathy, intraoperative local antibiotic injection, alone is appears adequate for preventing postoperative endophthalmitis.
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