Trial reportClinical oral investigations2026
Nd: YAG laser-assisted treatment of subgingival microbiota composition in stage III-IV periodontitis: a randomized controlled study.
Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
objectivesNd: YAG laser, a near-infrared laser, offers advantages such as sterilization, hemostasis, and tissue ablation, making it a promising adjunctive tool for minimally invasive periodontal treatment. This study aimed to evaluate the clinical efficacy of Nd: YAG laser-assisted nonsurgical treatment in stage III–IV periodontitis and its impact on the subgingival microbial community structure using 16 S rRNA sequencing. MATERIALS AND
methodsA total of 20 patients with stage III-IV periodontitis were randomly divided into a subgingival scaling and root planning (SRP group) (n = 10) and a Nd: YAG laser-assisted SRP group (Nd group) (n = 10). Clinical parameters were compared before and after treatment for 3 months, and subgingival plaque samples were collected for 16 S rRNA microbial analysis.
resultsBoth groups exhibited significant improvements in periodontal clinical parameters after treatment (P < 0.01), with greater gains in the Nd group (P < 0.05). Alpha diversity decreased after treatment in both (P < 0.05), more markedly in the Nd group (P < 0.01). Beta diversity analysis showed that significant clustering was formed in the subgingival plaque samples before and after treatment in both groups, with larger microbial shifts in the Nd group(P < 0.05). After treatment, the relationship network was significantly simplified.
conclusionsNon-surgical treatment significantly improved periodontal parameters in stage III-IV periodontitis patients, reducing subgingival microbiota diversity and optimizing its composition. CLINICAL RELEVANCE: Nd: YAG laser-assisted SRP demonstrated superior clinical outcomes versus SRP alone, with microbiological analysis confirming its adjunctive benefits and enhanced clinical efficacy.
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