SynthesisActa neurochirurgica2026
Robot-assisted versus frame-based stereoelectroencephalography (sEEG) electrode implantation in drug-resistant epilepsy: a meta-analysis of accuracy, efficiency, and safety.
Synthesis in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Perioperative adverse events and device malfunctions associated with ROSA cranial stereotactic robotic surgery a descriptive analysis of FDA MAUDE reports from 2016 to 2026.Journal of robotic surgery · 2026Article
- Robotic Arm Alignment System for Electrode Implantation in Invasive Epilepsy Monitoring: Clinical Experience and Accuracy in a Consecutive Patient Series with Comparison to the Literature.Journal of clinical medicine · 2026Article
- How I do it: a standardized robotic workflow for image-guided stereo-electroencephalography: technical description and institutional experience.Acta neurochirurgica · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the accuracy, efficiency, and safety of robot-assisted versus frame-based stereoelectroencephalography (sEEG) in patients with drug-resistant epilepsy.
methodsIn accordance with the PRISMA guidelines, a comprehensive literature search was conducted across four databases (PubMed, Scopus, Web of Science, and Cochrane) up to September 2025. We included comparative studies that evaluated robot-assisted versus frame-based sEEG in patients with drug-resistant epilepsy. A random-effects model was applied to calculate the mean difference (MD) and risk ratio (RR) with corresponding 95% confidence intervals (CI).
resultsEight retrospective comparative cohort studies (758 patients) were included. Regarding accuracy, there was no significant difference between the robot-assisted and frame-based sEEG in depth error (MD: 0.24 mm; 95% CI: -0.79 to 1.27), radial error (MD: 0.07 mm; 95% CI: -0.70 to 0.84), entry point error (EPE; MD: -1.35 mm; 95% CI: -2.74 to 0.04), and target point error (MD: -0.02 mm; 95% CI: -0.57 to 0.53). Robot-assisted sEEG demonstrated a significantly shorter overall operation time (MD: -32.58 min; 95% CI: -47.92 to -17.24) and operation time per electrode (MD: -6.55 min; 95% CI: -8.08 to -5.02). However, pre-implantation time (MD: -1.46 min; 95% CI: -14.02 to 11.11) and electrode number per patient (MD: 0.86; 95% CI: -0.84 to 2.56) were comparable between groups. There was no significant difference between the two groups in overall complication rates, including hemorrhagic events, neurological deficits, infections, and technical complications.
conclusionRobot-assisted sEEG significantly reduced both overall operation time and operation time per electrode compared with the frame-based group. Both techniques demonstrated comparable accuracy and safety profiles.
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