ArticleEndocrinology, diabetes & metabolism2026
The Response of Alpha-Aminoadipic Acid (2-AAA) to Short Term Lysine Ingestion in Healthy Individuals.
Article in Endocrinology, diabetes & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHigher circulating levels of the metabolite alpha-aminoadipic acid (2-AAA) associate with increased risk of diabetes and cardiometabolic disease. 2-AAA is metabolised from lysine, an essential dietary amino acid. However, the effects of lysine intake on plasma levels of 2-AAA were unclear. We measured post-prandial changes in plasma and urine levels of 2-AAA in healthy individuals in response to oral intake of
methodsWe recruited healthy individuals (N = 16) to an acute lysine challenge. We administered 5 g of
resultsWe found that
conclusionOur data suggest that orally ingested lysine is catabolised to 2-AAA over several hours. However, lysine ingestion also stimulates an increase in 2-AAA from endogenous sources. The rate of production and excretion differs between individuals, suggestive of controlled regulation of this metabolic pathway. Individuals with a higher WHR, indicative of greater visceral adiposity, may have increased excretion of 2-AAA, tryptophan, and kynurenine.
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