ArticleNMR in biomedicine2026
Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.
Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.NMR in biomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Cerebellar mutism syndrome (CMS) is a potential complication of pediatric posterior fossa tumor (pPFT) resection and may be related to disruption of the dentato-rubro-thalamic tract (DRTT). Intraoperative tractography allows assessment of changes to the DRTT during surgery. We evaluated macro- and microstructural changes of the DRTT by comparing pre- and intraoperative diffusion MRI (dMRI) tractography in patients with pPFT. Pre- and intraoperative T1-weighted and dMRI data were acquired to reconstruct the DRTT, while the arcuate fasciculus (AF) was reconstructed as a control tract. To evaluate macrostructural intraoperative alterations, tract volume and diameter were calculated. Microstructural changes were assessed using fractional anisotropy (FA) and mean diffusivity (MD), both globally and along the tract. Speech disturbances, as a characteristic symptom of CMS, were scored preoperatively and at hospital discharge, based on retrospective neurological reports. In 30 patients (aged > 21 months) with sufficient data quality, intraoperative reductions in tract volumes and diameters were observed (p < 0.05) in the decussating DRTT (d-DRTT) (-45.4% to -10%) and AF (-9.9% to -5.1%), while the non-decussating DRTT (nd-DRTT) remained stable. Right d-DRTT volume loss correlated with ventricular enlargement (r = -0.476, p = 0.022). Whole-tract analyses revealed increased FA in the AF and increased MD in the nd-DRTT and AF. Along-tract analyses demonstrated high variance of the MD in the DRTT cerebellar segments. Patients with postoperative speech disturbances showed higher variance of FA and MD along the DRTT, particularly in the left cerebellar segment. pPFT surgery affected the variation of the DRTT microstructure near the resection cavity, whereas the AF remained relatively stable. Although we did not find significant differences in patients with postoperative speech disturbances, we observed a much higher variability in MD in this group, suggesting a potential effect of DRTT disruption in these symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.