Evidence map›Paper›PMID 41721466›Full record

ArticleMolecular microbiology2026

SanA Plays a Role in Peptidoglycan Integrity in Escherichia coli.

Honoka Yamaguchi, Risa Ago, Yuhei O Tahara, Mari Inoue, Hironori Niki, Makoto Miyata, Daisuke Shiomi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Honoka YamaguchiDepartment of Life Science, College of Science, Rikkyo University, Toshima, Tokyo, Japan.
Risa AgoDepartment of Life Science, College of Science, Rikkyo University, Toshima, Tokyo, Japan.
Yuhei O TaharaGraduate School of Science, Osaka Metropolitan University, Osaka, Japan.
Mari InoueDepartment of Life Science, College of Science, Rikkyo University, Toshima, Tokyo, Japan.
Hironori NikiMicrobial Physiology Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Shizuoka, Japan.
Makoto MiyataGraduate School of Science, Osaka Metropolitan University, Osaka, Japan.
Daisuke ShiomiDepartment of Life Science, College of Science, Rikkyo University, Toshima, Tokyo, Japan.

Funding

JST CREST JPMJCR19S5NIG-JOINT 32A2025NIG-JOINT 47A2022NIG-JOINT 55A2024NIG-JOINT 57A2018NIG-JOINT 59A2021NIG-JOINT 60A2019NIG-JOINT 64A2023
6 · The paper itself

Abstract

Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In Escherichia coli, peptidoglycan required for cell elongation is synthesized by the Rod complex. Although RodZ is a non-essential component of this complex, its dysfunction leads to aberrant peptidoglycan synthesis, resulting in defects in cell shape and impaired growth. We previously isolated several suppressor mutants that restore growth in cells with impaired RodZ function (RMR cells). Most suppressor mutations mapped to components in the Rod complex other than RodZ. However, one suppressor mutation was identified in sanA, a gene not previously associated with the Rod complex. This mutation, sanA

Indexed as

Escherichia coliEscherichia coli ProteinsPeptidoglycanCell WallCytoskeletal ProteinsMutationPenicillin-Binding ProteinsPeptidoglycan GlycosyltransferaseSerine-Type D-Ala-D-Ala CarboxypeptidaseCytoskeletal ProteinsEscherichia coli ProteinsMRCB protein, E coliPenicillin-Binding ProteinsPeptidoglycanPeptidoglycan GlycosyltransferaseRodZ protein, E coliSerine-Type D-Ala-D-Ala CarboxypeptidaseE. colipeptidoglycanRod complex

Identifiers

PMID41721466
PMCPMC13046291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.