SynthesisJournal of viral hepatitis2026
Hepatitis E Infection in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis.
Synthesis in Journal of viral hepatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Prevalence of Hepatitis E Virus Infection Among Pregnant Women in Tunisia: Findings from a Large Cohort Study.Pathogens (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opportunistic infections are increasingly recognised in patients with inflammatory bowel disease (IBD), particularly among those receiving immunosuppressive therapy. Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide, yet its relevance in IBD remains insufficiently clarified. This systematic review and meta-analysis aimed to explore the association between HEV infection and IBD. A comprehensive literature search was performed in PubMed/MEDLINE and Google Scholar up to May 2025, identifying all studies reporting HEV infection in patients with ulcerative colitis (UC) or Crohn's disease (CD), with or without a control group. Study quality was assessed using the Joanna Briggs Institute Checklist for Analytical Cross-Sectional Studies. Six eligible studies encompassing 1316 IBD patients were included in the qualitative and quantitative synthesis. The pooled prevalence of anti-HEV IgG (HEV-G) antibodies among IBD patients was 13.5%, though with notable heterogeneity. Anti-HEV IgM (HEV-M) and HEV-RNA positivity rates were significantly lower, at 1.9% and 0.03%, respectively. When compared with the general population, IBD patients exhibited similar HEV-G and HEV-M prevalence, and comparable rates were observed between UC and CD subgroups. In contrast, immunocompromised transplant recipients demonstrated markedly higher HEV seropositivity. Sensitivity analyses confined to European cohorts indicated a modest rise in HEV-G and HEV-M levels, particularly among patients receiving intensified immunosuppression. Clinically, unexplained elevations of liver enzymes in IBD should prompt consideration of HEV infection. Overall, HEV prevalence in IBD parallels that of the general population; however, severe immunosuppression may predispose to persistent infection or liver-related complications, warranting routine testing for accurate diagnosis.
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