ArticleTrials2026
Using artificially intelligent text messaging to improve health behaviors to reduce cardiovascular risk: study protocol for a pragmatic randomized control trial.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06324981 (Using Artificially Intelligent Text Messaging Technology to Improve American Heart Association's Life's Essential 8 Health Behaviors), which is not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Artificially Intelligent Text Messaging Technology to Improve American Heart Association's Life's Essential 8 Health Behaviors: LE8 Bot + Backup
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0 citing papers in PubMed.
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Authors and funding
15 authors.
Funding
Abstract
backgroundCardiovascular (CV) disease and its risk factors such as hypertension, diabetes, and hyperlipidemia account for most chronic diseases experienced by adults in the US. The use of text-based "behavioral nudges" supports behavior change and self-management of chronic disease. Building upon our previous trial utilizing an artificially intelligent (AI) chatbot for medication adherence, the Chat for Heart Health randomized controlled trial aims to test the comparative effectiveness of 3 text-based methods of delivering "nudges" to change health behaviors to reduce cardiovascular disease risk in patients across 3 safety-net healthcare systems.
methodsAdult patients ages 18-89 with CV risk factors will be recruited from 3 health systems. A target of 2097 participants will be randomized to 3 study arms: generic text messaging, AI interactive chatbot messaging, and AI interactive chatbot messaging plus pharmacist support. Evaluation of the intervention and the program will be carried out using the RE-AIM and PRISM frameworks. The primary effectiveness outcome is the change in CV risk reduction behaviors as defined by the American Heart Association's Life's Essential 8 score. Secondary outcomes including patient self-efficacy scores, clinical events, healthcare utilization, and facilitators and barriers to implementation and adoption will also be assessed. DISCUSSION: Our large-scale pragmatic trial engages with patients and health systems who have traditionally not engaged in research, which presented substantial challenges yet will make our results more generalizable to diverse populations. Additionally, we engaged a diverse advisory panel made up of patients, community members, providers, and health systems leaders throughout the study to ensure sociocultural, linguistic, and community relevance. The results of this trial (if the intervention is effective) could lead to broader dissemination of a low-cost intervention to support behavior change to reduce CV risk.
trial registrationNCT06324981 (3/14/2024), https://clinicaltrials.gov/study/NCT06324981.
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