ArticleBMC musculoskeletal disorders2026
Efficacy of an intravenous acetaminophen/ibuprofen fixed-dose combination after total knee arthroplasty.
Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to evaluate the efficacy of the intravenous fixed-dose combination (IV FDC) of acetaminophen and ibuprofen after total knee arthroplasty (TKA).
methodsWe retrospectively analyzed TKA patients, dividing them into control and IV FDC groups using 1:1 propensity matching based on age and sex. The primary outcome was the Visual Analog Scale (VAS) score at 8 h, 16 h, 24 h, 48 h, 72 h, 96 h, and 120 h postoperatively. Secondary outcomes included opioid consumption, conversion to Morphine Milligram Equivalents (MME), and complications requiring additional consultations with other departments.
resultsA total of 70 patients were included in each group after propensity matching. The IV FDC group had significantly lower VAS scores at 96 h (3.1 ± 0.7 vs. 3.5 ± 1.3, p = 0.033) and 120 h (3.1 ± 0.8 vs. 3.7 ± 1.4, p = 0.003) compared to the control group. Opioid consumption was also significantly lower in the IV FDC group compared to the control group, both on POD 1 (51.9 ± 41.0 vs. 82.5 ± 64.3, p < 0.001) and in total consumption (131.9 ± 92.5 vs. 175.2 ± 129.3, p = 0.025).
conclusionThe use of an IV FDC of acetaminophen and ibuprofen after TKA significantly reduced opioid consumption and demonstrated a modest improvement in pain scores at later postoperative time points.
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