Observational studyBMC infectious diseases2026
Association between shock‑lactate index and 28-day mortality in patients with sepsis-associated AKI: a MIMIC-IV database analysis.
Observational study in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Admission shock indices and lactate for mortality risk stratification in non-traumatic hypotensive patients.Irish journal of medical science · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAlthough the Shock–Lactate Index (SLI) has been increasingly explored as a composite physiological indicator, its association with outcomes in patients with sepsis-associated acute kidney injury (SA-AKI) remains unclear.
methodsThis retrospective observational study included 9,873 patients with SA-AKI from the MIMIC-IV database (2008–2019). Sepsis and AKI were defined according to Sepsis-3 and KDIGO criteria, respectively. The association between SLI and 28-day all-cause mortality was evaluated using Kaplan–Meier survival analysis and multivariable Cox proportional hazards models. Restricted cubic splines with four knots were applied to explore potential non-linear relationships. Models were adjusted for clinically relevant covariates, including Sequential Organ Failure Assessment (SOFA) score, APACHE II score, organ support measures, and selected laboratory variables. Prespecified subgroup analyses were conducted to assess effect modification across clinically relevant strata.
resultsAmong patients with SA-AKI, higher SLI levels were significantly associated with increased 28-day all-cause mortality (P < 0.001). Kaplan–Meier analysis demonstrated progressively lower survival rates across increasing SLI quartiles, with the highest quartile exhibiting the poorest survival (log-rank P < 0.0001). In multivariable Cox models, elevated SLI remained independently associated with higher mortality risk. Restricted cubic spline analysis indicated a non-linear association between SLI and mortality (P for non-linearity < 0.001). Subgroup analyses showed generally consistent associations across patient subgroups, with significant interactions observed in strata defined by age, pneumonia, chronic kidney disease, ischemic heart disease, SOFA score and APACHE II score (all P for interaction < 0.05).
conclusionsHigher SLI levels are independently associated with increased 28-day mortality in patients with sepsis-associated acute kidney injury. SLI shows promise as a prognostic tool for assessing mortality risk in SA-AKI patients, providing clinicians with more accurate information to optimize treatment strategies and improve patient outcomes.
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