ArticleCNS neuroscience & therapeutics2026
The Dual Associations of Peripheral Inflammatory Cells With Brain Reorganization in Insular Gliomas With/Without Epilepsy: An Exploratory Analysis.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correction to "The Dual Associations of Peripheral Inflammatory Cells With Brain Reorganization in Insular Gliomas With/Without Epilepsy: An Exploratory Analysis".CNS neuroscience & therapeutics · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
objectivesThe insula was invaded by gliomas and epilepsy occurred frequently. Our study aimed to reveal brain reorganization and explore potential peripheral biomarkers that reflect these processes.
methods51 insular glioma-related epilepsy (IRE) and 52 without epilepsy (IRnE) patients were included. Deep learning was used for tumor segmentation to generate masks for subsequent analyses. Virtual brain grafting was applied to eliminate the mass effect. Morphological analyses relied on MATLAB, SPM, and CAT12. Statistical analyses included χ
resultsIncreased gyrification (GI) occurred on the contralateral side of IRnE. Increased gray matter volume and toroidal GI (Toro GI) appeared on the same and contralateral sides of IRE, respectively. Elevated Toro GI showed an initial predictive value for the control of postoperative epilepsy and was negatively associated with blood white cell, monocyte, and neutrophil counts in IRE. The opposite relationship was observed for GI in IRnE. SIGNIFICANCE: The brain would conduct different reorganization models to adapt to IRE and IRnE. These processes may be associated with specific peripheral inflammatory cells. Longitudinal studies and explorations of more specific biomarkers are necessary for elucidating the causal relationships and providing suggestions for therapeutic concepts of different insular glioma subtypes.
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Registered trials
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