Evidence map›Paper›PMID 41721164›Full record

ArticleAnnals of surgical oncology2026

The Role of Surgery in the Management of Intestinal Diffuse Large B-Cell Lymphoma (DLBCL): A Propensity Score-Matched Analysis.

Kefan Dai, Yue Li, Di Fu, Shuchun Li, Bingyu Zuo, Junjun Ma, Minhua Zheng, Li Wang, Lu Zang

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kefan Dai *Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yue Li *Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Di Fu *State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuchun LiDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bingyu ZuoDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junjun MaDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Minhua ZhengDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li WangState Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lu ZangDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zanglu@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of surgery in the management of intestinal diffuse large B-cell lymphoma (DLBCL) remains controversial. The study aimed to investigate the efficacy of surgery and explore the prognostic factors for patients with intestinal DLBCL.

methodA total of 118 patients diagnosed with intestinal DLBCL who received systemic therapy from 2011 to 2020 were retrospectively enrolled. Patients were divided into the conservative treatment group and the surgical treatment group based on whether they underwent surgical intervention prior to systemic therapy. Propensity score matching (PSM) analysis was utilized to control the confounding factors. Survival and Cox regression analyses were performed to evaluate the long-term outcome and prognostic risk factors.

resultsPatients in the surgical treatment group had significantly higher progression-free survival (PFS) rates than patients who received conservative treatment (3-year PFS: 84.6% vs. 35.9%, p<0.001; 5-year PFS: 53.8% vs. 28.2%, p=0.021). The overall survival (OS) rates of the surgery group were also significantly higher than those of the conservative treatment group (3-year OS: 87.2% vs. 43.6%, p<0.001; 5-year OS: 56.4% vs. 30.8%, p=0.022). Surgical treatment was associated with a higher complete response rate and a lower disease progression/relapse rate (complete response rate: 87.2% vs. 53.8%, p=0.001; progression/relapse rate: 10.3% vs. 28.2%, p=0.044). Multivariate Cox regression analysis indicated that serum lactate dehydrogenase level and surgical intervention were independent prognostic factors for both PFS and OS, whereas bone marrow involvement was an independent prognostic factor for PFS.

conclusionCombined surgical treatment manifested a better survival outcome than conservative treatment for patients with intestinal DLBCL. Serum lactate dehydrogenase level, bone marrow involvement, and surgical intervention are independent prognostic factors for survival.

Indexed as

Conservative TreatmentIntestinal NeoplasmsLymphoma, Large B-Cell, DiffuseAgedAntineoplastic Combined Chemotherapy ProtocolsFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisPropensity ScoreRetrospective StudiesSurvival RateDiffuse large B-cell lymphomaIntestinal lymphomaPrognosisSurgery

Identifiers

PMID41721164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.