Evidence map›Paper›PMID 41721151›Full record

ArticleWorld journal of pediatrics : WJP2026

Management of pulmonary thromboembolism in children: an evidence-based expert consensus.

Li-Nan Zeng, Ying-Xue Zou, Hai-Lin Zhang, Li-Na Chen, De-Hui Chen, Xin-Xin Chen, Xing Chen, Zhi-Min Chen, Xiao-Yan Dong, Liang Huang and 21 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of pediatrics : WJP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Li-Nan ZengDepartment of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University; Children's Medicine Key Laboratory of Sichuan Province, Chengdu, China.
Ying-Xue ZouDepartment of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.
Hai-Lin ZhangDepartment of Pediatric Respiratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Li-Na ChenDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
De-Hui ChenDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xin-Xin ChenHeart Center, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Xing ChenDepartment of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Zhi-Min ChenDepartment of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Xiao-Yan DongDepartment of Pulmonology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Liang HuangDepartment of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University; Children's Medicine Key Laboratory of Sichuan Province, Chengdu, China.
Yi JiDepartment of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yong-Mei JiangDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Zhi-Ping LiDepartment of Clinical Pharmacy, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
En-Mei LiuDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China.
Shu-Hua LuoDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Xiao-Feng NiDepartment of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University; Children's Medicine Key Laboratory of Sichuan Province, Chengdu, China.
Guang-Min NongDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yun PengDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Su-Yun QianPediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Tian-You WangHematology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Xin-Yu YuanDepartment of Radiology, The Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Hao ZhangHeart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children's Medical Center, National Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hong ZhangDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiao-Bo ZhangDepartment of Respiratory Medicine, Children's Hospital of Fudan University, Shanghai, China.
De-Yu ZhaoDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
Shun-Ying ZhaoDepartment of Respiratory Disease, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Xiu-Fang ZhaoKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
Kai-Yu ZhouKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
Quan LuDepartment of Pulmonology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. luquan-sh@vip.sina.com.
Ling-Li ZhangDepartment of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University; Children's Medicine Key Laboratory of Sichuan Province, Chengdu, China. zhanglingli@scu.edu.cn.
Han-Min LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. liuhm@scu.edu.cn.ORCID 0000-0002-4633-911X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary thromboembolism is rare in children, but can be life-threatening. Timely diagnosis and treatment of pulmonary thromboembolism are crucial for reducing mortality associated with pulmonary thromboembolism in children. While guidelines for pulmonary thromboembolism in adults are available, guidelines for standardized diagnosis and management of pulmonary thromboembolism in children are not. This expert consensus aims to provide recommendations for the management of pulmonary thromboembolism in children based on the current best available evidence. DATA SOURCES: Following the World Health Organization Handbook for Guideline Development, the expert panel consisted of 30 members from different clinical areas. The panel identified clinical questions through systematic reviews and expert discussions, systematically reviewed evidence on pulmonary thromboembolism in children, and evaluated the quality of the evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Using the GRADE Evidence to Decision Framework, the panel made recommendations, considering the effects of interventions, resource use, values and preferences, equity, acceptability, and feasibility.

resultsThe epidemiology, classification, and pathophysiology characteristics are summarized. The expert panel developed 33 recommendations addressing 20 questions related to diagnosis steps, treatment approaches such as anticoagulant therapy, thrombolysis therapy, catheter-based interventional therapy, surgical embolectomy, multidisciplinary team, and treatment of patients with comorbidities, prognosis, education, as well as follow-up. Among these, 18 are weak recommendations based on very low quality evidence, and 15 are good practice statements.

conclusionsThe expert panel provided recommendations for pulmonary thromboembolism in children based on available evidence, which was generally low in quality and volume. The panel urges further research on early identification and diagnosis strategies, preventive and therapeutic regimens, and long-term management for pulmonary thromboembolism.

Indexed as

Pulmonary EmbolismAnticoagulantsChildEvidence-Based MedicineHumansThrombolytic TherapyAnticoagulantsChildrenDiagnosisExpert consensusManagementPulmonary thromboembolismTreatment

Identifiers

PMID41721151
PMCPMC13076377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.