ReviewAmino acids2026
Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders.
Review in Amino acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Spermidine in the aging brain: mechanisms, preclinical evidence, and clinical perspectives.Molecular biology reports · 2026Review
- Understanding the Mechanistic Connection between Dysbiosis and Polyamine Regulation in Oral and Intestinal Inflammation- Role of Tregs and Th17 Cells.Journal of cellular immunology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative disorders are an Critical worldwide issue, characterized by progressive neuronal loss and cognitive decline with limited effective therapies. A central problem in these conditions is chronic neuroinflammation, oxidative stress, and disrupted cellular homeostasis. Polyamines, such as putrescine, spermidine, and spermine-small molecules-play vital roles in maintaining neuronal function, regulating autophagy, and protecting against cellular stress. Notably, spermidine-induced autophagy has emerged as a key mechanism linking polyamine metabolism to neuronal longevity and cognitive resilience. Recent studies highlight that probiotics and specific gut microbes can effectively modulate host polyamine production through the gut-brain axis, influencing neural health. This microbial modulation has been shown to restore polyamine balance, enhance antioxidant defenses, and reduce neuroinflammatory responses. Targeting microbiota-driven polyamine synthesis is emerging as a promising, non-invasive approach for neuroprotection. This review consolidates the current understanding of polyamine biology and microbial influences, highlighting their therapeutic potential. Exploring these interactions offers new avenues for innovation in combatting neurodegenerative disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.