ReviewAAPS PharmSciTech2026
From Anatomy to Application: A Comprehensive Review of Nanovesicular Systems for Otic Drug Delivery.
Review in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human ear is a complicated organ with unique anatomy and composition. Ototopical administration has become an interest recently. However, an effective drug delivery to the ear is not easy, as there are many otic obstacles such as tympanic membrane, blood labyrinth barrier, endolymph-perilymph barrier, and middle inner ear barriers (oval window and round window). Nanovesicular drug delivery carriers have the ability to entrap hydrophilic and lipophilic drugs, increase drug stability, sustain residence time, enhance otic permeability, and increase bioavailability. The objectives of this review are to describe ear anatomy, different otic diseases, and challenges for ear drug delivery. Also, it discusses different nanovesicular drug delivery systems including their characterization methods, advantages, limitations, and applications in ear drug delivery for the treatment of different ear diseases. These systems can manage solubility, safety, bioavailability, efficiency, and stability issues existing in conventional drug delivery systems.
Indexed as
Identifiers
41721056What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.