Evidence map›Paper›PMID 41721055›Full record

ArticlePediatric research2026

Blood lactate kinetics as biomarkers of MRI brain injury in neonatal encephalopathy.

Giulia Bassani, Marion Décaillet, Patric Hagmann, Jean-Baptiste Ledoux, Anita C Truttmann, Juliane Schneider

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Giulia BassaniClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. giulia.bassani00@gmail.com.
Marion DécailletClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Patric HagmannDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Jean-Baptiste LedouxDepartment of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Anita C TruttmannClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Juliane SchneiderClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn neonatal encephalopathy (NE), early biomarkers are needed to enhance prognostic accuracy. We hypothesized that blood lactate kinetics correlate with magnetic resonance imaging (MRI)-based brain injury severity.

methodsIn this prospective cohort study, patients with NE admitted to a tertiary neonatal intensive care unit underwent brain MRI within the first week of life. Injury severity was graded using a validated MRI scoring system, with neonates categorized into low severity (LS) or high severity (HS) groups based on the 75th percentile of the total score. Lactate kinetics were evaluated through peak lactate levels, time to lactate normalization (TLN), and area under the curve (AUC). Associations between lactate kinetics and MRI scores were analyzed.

resultsAmong forty‑eight neonates, 83% underwent therapeutic hypothermia. Compared with the LS group, the HS group had more seizures, higher Thompson and Sarnat scores, and more abnormal neurological exams at discharge. Peak lactate was higher in the HS group (p = 0.02) and correlated with MRI grey matter subscores (p = 0.004). Lactate AUC and TLN were positively associated with MRI total and grey matter scores (all p < 0.01).

conclusionLactate kinetics are associated with MRI-assessed brain injury severity in NE and may help stratification to tailor therapeutic strategies. IMPACT: Blood lactate kinetics are associated with MRI-assessed brain injury severity in neonates with neonatal encephalopathy (-NE-). This study highlights the value of serial lactate measures, beyond single time-point levels, in early prognostication. Combining biochemical markers with imaging scores may improve the identification of infants at high risk of adverse outcomes. These findings support the potential use of lactate kinetics to stratify patients and guide future therapeutic strategies.

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PMID41721055

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