Evidence map›Paper›PMID 41721052›Full record

ArticleArchives of gynecology and obstetrics2026

Association between maternal anti-Ro and anti-La antibody levels and congenital heart block: a 20-year cohort study.

Gabriel Duque Pannain, Joelma Queiroz Andrade, Marco Antônio Borges Lopes, Fabrício Marcondes Camargo, Vera Lúcia Jornada Krebs, Werther Brunow de Carvalho, Rossana Pulcinelli Vieira Francisco

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Article in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Gabriel Duque PannainDivision of Fetal Medicine, Department of Obstetrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil. gabrielduquep@gmail.com.
Joelma Queiroz AndradeDivision of Fetal Medicine, Department of Obstetrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil.
Marco Antônio Borges LopesDivision of Fetal Medicine, Department of Obstetrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil.
Fabrício Marcondes CamargoDivision of Fetal Medicine, Department of Obstetrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil.
Vera Lúcia Jornada KrebsDivision of Neonatology, Department of Pediatrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil.
Werther Brunow de CarvalhoDivision of Neonatology, Department of Pediatrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil.
Rossana Pulcinelli Vieira FranciscoDivision of Fetal Medicine, Department of Obstetrics, School of Medicine, University of São Paulo (FMUSP), São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between maternal anti-Ro and anti-La antibody levels and the occurrence of congenital heart block (CHB) in fetuses and newborns.

methodsThis retrospective cohort study included 182 pregnant women with positive anti-Ro and/or anti-La antibodies who received prenatal care at our tertiary center between 2002 and 2022. Maternal clinical, laboratory, and obstetric variables were analyzed.

resultsThirteen fetuses (7.1%) were diagnosed with CHB. Mothers of affected fetuses had significantly higher anti-Ro (median 240 vs. 42; p < 0.001) and anti-La (median 150 vs. 10; p < 0.001) levels. Anti-La positivity was more frequent in the CHB group (76.9% vs. 42.6%; p = 0.017). Lower complement C4 levels (p = 0.008) and disease duration of less than 1 year since diagnosis (p = 0.008) were also associated with CHB. Preconception hydroxychloroquine and prednisone use were less frequent in affected pregnancies (p = 0.044 and p = 0.039, respectively).

conclusionHigher maternal anti-Ro and anti-La antibody levels were significantly associated with fetal CHB. Preconception hydroxychloroquine may provide a protective effect. Early diagnosis and specialized care are essential for optimizing neonatal outcomes.

Indexed as

Antibodies, AntinuclearHeart BlockAdultCohort StudiesComplement C4FemaleHumansInfant, NewbornLupus Erythematosus, SystemicPregnancyPregnancy ComplicationsRetrospective StudiesSS-B AntigenAntibodies, AntinuclearComplement C4SS-A antibodiesSS-B antibodiesSS-B AntigenAnti-La antibodiesAnti-Ro antibodiesCongenital heart blockLupus erythematosusPregnancySjögren’s syndrome

Identifiers

PMID41721052
PMCPMC12923472

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