Evidence map›Paper›PMID 41721014›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Molecular features in gangliogliomas: a systematic review.

Benedito Jamilson Araújo Pereira, Sueli Mieko Oba-Shinjo, Ivy Karoline Herculano de Azevedo, Yuri Reis Casal, Wen Hung Tzu, Antônio Nogueira de Almeida, Wellingson Silva Paiva, Suely Kazue Nagahashi Marie

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benedito Jamilson Araújo PereiraLaboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Avenida Dr Arnaldo, 455/4º Andar/Sala 4110, São Paulo, SP, Brazil. benedito.jamilson@hotmail.com.
Sueli Mieko Oba-ShinjoLaboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Avenida Dr Arnaldo, 455/4º Andar/Sala 4110, São Paulo, SP, Brazil.
Ivy Karoline Herculano de AzevedoLaboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Avenida Dr Arnaldo, 455/4º Andar/Sala 4110, São Paulo, SP, Brazil.
Yuri Reis CasalPathological Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Wen Hung TzuHospital das Clínicas HCFMUSP, Divisão de Neurocirurgia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Antônio Nogueira de AlmeidaHospital das Clínicas HCFMUSP, Divisão de Neurocirurgia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Wellingson Silva PaivaHospital das Clínicas HCFMUSP, Divisão de Neurocirurgia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, Brazil.
Suely Kazue Nagahashi MarieLaboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de São Paulo, Avenida Dr Arnaldo, 455/4º Andar/Sala 4110, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn the present study, a systematic revision in the Medline was conducted to determine the somatic mutation in gangliogliomas.

methodsA Medline search for relevant publications up to October 2024 using the key phrase "ganglioglioma mutation" led to the retrieval of 297 studies. This corpus provided the basis for the present review. The records without abstract or descriptions of somatic mutations were excluded. Only records in the English language were considered.

resultsA total of 43 papers were evaluated, reporting a total of 1360 cases of ganglioglioma. Among them, 528 cases presented mutations in 6 genes: BRAF

conclusionBRAF

Indexed as

Brain NeoplasmsGangliogliomaMutationHumansProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-rafProto-Oncogene Proteins p21(ras)Receptor, Fibroblast Growth Factor, Type 1BRAF protein, humanFGFR1 protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-rafProto-Oncogene Proteins p21(ras)Receptor, Fibroblast Growth Factor, Type 1GangliogliomaMolecularMutations

Identifiers

PMID41721014
PMCPMC12923415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.