ArticleScientific reports2026
Coronary artery calcification is associated with reduced survival in mechanically ventilated COVID-19 patients in the MaastrICCht cohort.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In mechanically ventilated COVID-19 patients, a higher degree of coronary artery calcification (CAC) has been associated with increased severity of multi-organ failure. Furthermore, non-survivors showed worse development of multi-organ failure over time compared to survivors with COVID-19. Nevertheless, it remains unclear whether more CAC is associated with worse long-term survival. Therefore, we studied the association between CAC and one-year survival. In a prospective cohort of 241 mechanically ventilated patients who underwent chest CT scans for clinical evaluation of critical disease, CAC was scored using a semi-quantitative 12-point grading system. Cox proportional hazards analyses were used to investigate the association between CAC score (continuous and tertiles) and one-year survival in crude models and models adjusted for risk factors. In the crude model, a 1-point higher CAC score was associated with a higher hazard ratio (HR) (with 95% confidence interval (CI)) of 1.13 (95%CI: 1.08;1.19, p-value: <0.001). Compared to the lowest tertile (n = 85), a higher mortality was shown for the medium (n = 81) and the highest (n = 75) tertiles, HR 1.21 (95%CI: 0.73;2.02, p-value:0.443) and HR 3.32 (95%CI: 2.10;5.27, p-value:<0.001), respectively. After adjustment for age, sex and APACHE-II score, and comorbidities, a higher CAC score was associated with statistically significant worse one-year survival HR 2.07 (95% CI: 1.18–3.63, p-value:0.012). More coronary artery calcifications (CAC) are associated with worse one-year survival in patients on mechanical ventilation for severe COVID-19.
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