Blood MMP-7 and TNF-α levels as potential prognostic biomarkers for adult pulmonary Langerhans cell histiocytosis.

Amira Benattia, Raphaël Porcher, Stéphane Terry, Muriel Andrieu, Gwenaël Lorillon, Abdellatif Tazi

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Amira BenattiaINSERM, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Université Paris Cité and Université Sorbonne Paris Nord, 75004, Paris, France.

Raphaël PorcherINSERM, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Université Paris Cité and Université Sorbonne Paris Nord, 75004, Paris, France.

Stéphane TerryCentre National de Référence des Histiocytoses, Hôpital Saint-Louis, Service de Pneumologie, Assistance Publique-Hôpitaux de Paris, 1, Avenue Claude Vellefaux, 75475, Paris Cedex 10, France.

Muriel AndrieuUniversité Paris Cité, 75006, Paris, France.

Gwenaël LorillonCentre National de Référence des Histiocytoses, Hôpital Saint-Louis, Service de Pneumologie, Assistance Publique-Hôpitaux de Paris, 1, Avenue Claude Vellefaux, 75475, Paris Cedex 10, France.

Abdellatif TaziCentre National de Référence des Histiocytoses, Hôpital Saint-Louis, Service de Pneumologie, Assistance Publique-Hôpitaux de Paris, 1, Avenue Claude Vellefaux, 75475, Paris Cedex 10, France. abdellatif.tazi@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The natural history of pulmonary Langerhans cell histiocytosis (PLCH) is unpredictable. Therefore, the identification of prognostic biomarkers for PLCH represents a major goal for better management of patients. The aim of this study was to evaluate the levels of various blood mediators in PLCH patients at diagnosis and explore their relationships with forced expiratory volume in one second (FEV

Indexed as

Histiocytosis, Langerhans-CellMatrix Metalloproteinase 7Tumor Necrosis Factor-alphaAdultBiomarkersFemaleForced Expiratory VolumeHumansMaleMiddle AgedPrognosisBiomarkersMatrix Metalloproteinase 7MMP7 protein, humanTumor Necrosis Factor-alphaBlood biomarkersChemokinesCytokinesFEV1Lung functionMetalloproteinasesMortalityPulmonary Langerhans cell histiocytosis

Identifiers

PMID41720965

DOI10.1038/s41598-026-40540-4

PMCPMC13022174

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.