SynthesisLangenbeck's archives of surgery2026
Three-dimensional printing-guided surgical localization in breast-conserving surgery: A systematic review of oncologic and aesthetic outcomes.
Synthesis in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast-conserving treatment (BCT), comprising surgery followed by radiotherapy, is a standard approach for early-stage breast cancer. Achieving negative surgical margins while preserving aesthetic integrity remains a challenge. Three-dimensional printing (3DP) technologies offer new opportunities for surgical precision through patient-specific breast surgical guides (3DP-BSGs), yet their application in breast-conserving surgery (BCS) remains under investigation.
methodsThis systematic review followed PRISMA guidelines. A comprehensive search was conducted in PubMed, Embase, Cochrane Library, Scopus, Web of Science, and CNKI from January 2015 to December 2025. Studies evaluating 3DP-BSG or advanced localization techniques in BCS were included. Outcomes assessed included margin status, recurrence, aesthetic results, procedural efficiency, and surgeon satisfaction.
resultsFourteen studies involving 1,126 patients were included. Among the 587 patients in the 3DP-BSG group, positive margin rates ranged from 0% to 18.2%, which is generally lower than the historical rates achieved with conventional methods. Recurrence rates in post-neoadjuvant chemotherapy (NACT) patients were also lower than previously reported benchmarks. 3DP-BSGs, typically derived from supine MRI, provided accurate tumor localization and reduced reliance on intraoperative ultrasound or wire placement. Aesthetic outcomes and surgeon satisfaction were inconsistently reported but showed favorable trends.
conclusion3DP-BSG is a non-invasive, radiation-free alternative to traditional localization methods in BCS, with potential advantages in margin control and workflow efficiency, especially in post-NACT settings. While early results are encouraging, current evidence is limited by heterogeneity and small sample sizes. Larger randomized controlled trials with standardized aesthetic and oncologic endpoints are needed to confirm clinical utility and facilitate integration into standard breast cancer surgery protocols.
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