Evidence map›Paper›PMID 41720895›Full record

ArticleNPJ digital medicine2026

CancerLLM: a large language model in cancer domain.

Mingchen Li, Zaifu Zhan, Jiatan Huang, Jeremy Yeung, Kai Ding, Anne Blaes, Steven Johnson, Hongfang Liu, Hua Xu, Rui Zhang

Abstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingchen LiDivision of Computational Health Sciences, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Zaifu ZhanDepartment of Electrical and Computer Engineering, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Jiatan HuangDivision of Computational Health Sciences, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Jeremy YeungDivision of Computational Health Sciences, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Kai DingDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA.
Anne BlaesDivision of Hematology, Oncology and Transplantation, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Steven JohnsonInstitute for Health Informatics, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Hongfang LiuMcWilliams School of Biomedical Informatics, UTHealth Houston, Houston, TX, USA.
Hua XuDepartment of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.
Rui ZhangDivision of Computational Health Sciences, University of Minnesota Twin Cities, Minneapolis, MN, USA. ruizhang@umn.edu.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRDR01AG078154 · NIA · UNIVERSITY OF MINNESOTA · PI HUA XU, RUI ZHANG · 2022 to 2026
$4.2M
A Translational Informatics Framework to Mine Efficacy and Safety of Dietary SupplementsR01AT009457 · NCCIH · UNIVERSITY OF MINNESOTA · PI RUI ZHANG · 2017 to 2026
$4.1M
SCH: A New Computational Framework for Learning from Imbalanced Biomedical DataR01CA287413 · NCI · UNIVERSITY OF MINNESOTA · PI CUI, YING, SUN, JU · 2023 to 2025
$1.2M
FDA HHS U01 FD008720National Institute on Aging grant R01AG078154National Institutes of Health's National Center for Advancing Translational Science UM1TR004405National Institutes of Health's National Center for Complementary and Integrative Health R01AT009457NCATS NIH HHS UM1 TR004405NCCIH NIH HHS R01 AT009457NCI NIH HHS R01 CA287413NCI NIH HHS R01CA287413NIA NIH HHS R01 AG078154
6 · The paper itself

Abstract

Medical large language models (LLMs) perform well on medical NLP tasks, but lack models tailored for cancer phenotyping and diagnosis. Moreover, having tens of billions of parameters increases the computational burden in healthcare settings. To this end, we present CancerLLM, a 7-billion-parameter Mistral-style model trained on 2.7 M clinical notes and 515 K pathology reports across 17 cancer types, followed by fine-tuning on cancer phenotype extraction and diagnosis generation tasks. Our evaluation demonstrated that CancerLLM achieved strong performance on internal benchmarks, with F1 score of 91.78% on phenotyping extraction and 86.81% on diagnosis generation. It outperformed existing LLMs, with an average F1 score improvement of 9.23%. Additionally, the CancerLLM demonstrated its efficiency on time and GPU usage, and robustness comparing with other LLMs. We demonstrated that CancerLLM can potentially provide an effective and robust solution to advance clinical research and practice in cancer domain.

Identifiers

PMID41720895
PMCPMC13036061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.