Evidence map›Paper›PMID 41720802›Full record

ArticleNature communications2026

Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy.

Lior Goldberg, Eric R Haas, Jiaqi Wu, Bryan Garcia, Ryan Urak, Vibhuti Vyas, Ruby Espinosa, Tamara Munoz, Shirley Bierkatz, Khyatiben V Pathak and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Lior GoldbergDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA. lgoldberg@coh.org.ORCID http://orcid.org/0000-0002-1643-7616
Eric R HaasDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-2962-9331
Jiaqi WuDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Bryan GarciaDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Ryan UrakDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Vibhuti VyasDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Ruby EspinosaDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Tamara MunozDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Shirley BierkatzDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Khyatiben V PathakIntegrated Mass Spectrometry Shared Resource, City of Hope, Duarte, CA, USA.
Nathaniel P HansenIntegrated Mass Spectrometry Shared Resource, City of Hope, Duarte, CA, USA.
Patrick PirrotteIntegrated Mass Spectrometry Shared Resource, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-1360-6039
Jyotsana SinghalDivision of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Duarte, CA, USA.
James L FigarolaDivision of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Ricardo Zerda NoriegaCore of Electron Microscopy, City of Hope, Duarte, CA, USA.
Zhuo LiCore of Electron Microscopy, City of Hope, Duarte, CA, USA.
Dasol WiDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Erin TanakaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Ramon Klein GeltinkDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0003-4610-3059
Min-Hsuan ChenIntegrative Genomics Core, City of Hope and Beckman Research Institute, Duarte, CA, USA.
Xiwei WuIntegrative Genomics Core, City of Hope and Beckman Research Institute, Duarte, CA, USA.
Jamie R WagnerDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Jinny PaulDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Mary C ClarkDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-1672-2684
Dat NgoDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Ibrahim AldossDepartment of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-9564-4498
Stephen J Forman *Department of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-2803-4152
Xiuli Wang *Department of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, Beckman Research Institute, City of Hope, Duarte, CA, USA. xiuwang@coh.org.ORCID http://orcid.org/0000-0001-5964-4327

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5K12CA001727-29U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA033572
6 · The paper itself

Abstract

Although most patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) receiving CD19-targeted chimeric antigen receptor (CAR) T cell therapy achieve remission, loss of CAR T cell functionality and subsequent relapse remains an unmet therapeutic need. Herein, we apply an integrative approach to study the immunometabolism of pre- and post-infusion CD19-CAR T cells of patients with relapsed/refractory B-ALL. Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders. Post-infusion CAR T cells in bone marrow (BM) of LTR have high immunometabolic plasticity and mTOR-pS6 expression supported by the BM microenvironment. Transient inhibition of mTOR during manufacture induces metabolic reprogramming and enhances anti-tumor activity of CAR T cells. Our findings provide insight into immunometabolic determinants of long-term response and suggest a therapeutic strategy to improve long-term remission.

Indexed as

Antigens, CD19Immunotherapy, AdoptiveReceptors, Chimeric AntigenT-LymphocytesBone MarrowHumansMetabolic ReprogrammingMitochondriaOxidative PhosphorylationPentose Phosphate PathwayTOR Serine-Threonine KinasesAntigens, CD19MTOR protein, humanReceptors, Chimeric AntigenTOR Serine-Threonine Kinases

Identifiers

PMID41720802
PMCPMC13035890

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.