ArticleNature communications2026
Nonlinear genomic selection index accelerates multi-trait crop improvement.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Genetic dissection of cold tolerance across developmental stages in sorghum reveals stage-specific haplotypes and potential trade-offs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- GE-BiFormer: bidirectional cross-attention integration of genomic and Enviromic data for genotype-by-environment prediction in maize.Briefings in bioinformatics · 2026Article
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8 authors.
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Abstract
Linear phenotypic and genomic selection indices assume additivity and linearity, limiting their ability to exploit nonlinear trait relationships. Here, we introduce the Quadratic Genomic Selection Index (QGSI), a genomic extension of the quadratic phenotypic selection index (QPSI) that integrates genomic estimated breeding values (GEBVs) within a unified quadratic framework. QGSI combines additive, squared, and cross-product terms of GEBVs, enabling phenotype-free, rapid-cycle multi-trait selection while capturing genome-wide nonlinear relationships. We evaluate QGSI using two genomic prediction strategies: (i) a maximum-likelihood additive genomic model, and (ii) a nonlinear multi-trait Gaussian kernel model that accommodates epistatic signals. Using 10 simulated maize selection cycles and two real maize and five wheat real datasets, QGSI achieves the highest selection response and the lowest prediction error variance relative to linear and quadratic phenotypic and genomic indices. Thus, combining nonlinear genomic prediction with quadratic selection indices provides a general strategy for accelerating multi-trait crop improvement.
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